sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2rc4 | ACO | Histone acetyltransferase KAT6A |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 1.000 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.637 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.627 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.623 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.614 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.613 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.603 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.561 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.554 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.541 | |
| 1p0h | COA | Mycothiol acetyltransferase | 2.3.1.189 | 0.496 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.489 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.478 | |
| 1ozp | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.475 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.475 | |
| 2oor | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.473 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.469 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.467 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.466 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.466 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.465 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.464 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.462 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.461 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.461 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.460 | |
| 1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.460 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.458 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.458 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.457 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.457 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.455 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.455 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.454 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.454 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.454 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.454 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.454 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.454 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.453 | |
| 5ahs | FAD | Acyl-CoA dehydrogenase | / | 0.453 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.451 | |
| 3fcj | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.450 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.449 | |
| 4irn | FAD | AnaB | / | 0.449 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.448 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.448 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.448 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.447 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.447 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.447 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.447 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.446 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.446 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.446 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.445 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.445 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.445 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.445 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.444 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.444 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.444 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.444 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.442 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.442 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.442 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.442 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.441 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.440 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 |