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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2r9w23CBeta-lactamase3.5.2.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2r9w23CBeta-lactamase3.5.2.61.000
2pu2DK2Beta-lactamase3.5.2.60.560
2r9xWH6Beta-lactamase3.5.2.60.550
1xgjHTCBeta-lactamase3.5.2.60.545
1l2sSTCBeta-lactamase3.5.2.60.496
1xgiNSTBeta-lactamase3.5.2.60.492
1tehNADAlcohol dehydrogenase class-31.1.1.10.487
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.467
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.454
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.452
2givACOHistone acetyltransferase KAT8/0.451
3ig6438Urokinase-type plasminogen activator3.4.21.730.450
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.448
4j2wFADKynurenine 3-monooxygenase/0.448
1w6hTITPlasmepsin-23.4.23.390.446
2iko7IGRenin3.4.23.150.446
3b6zCO7Enoyl reductase LovC10.446
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.446
3d91REMRenin3.4.23.150.445
2ikuLIYRenin3.4.23.150.444
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.443
3sufSUEPolyprotein/0.443
1xe55FEPlasmepsin-23.4.23.390.441
2c20NADUDP-glucose 4-epimerase/0.441
3oibFDAPutative acyl-CoA dehydrogenase/0.440
5dp2NAPCurF/0.440