Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pzn393Aldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pzn393Aldose reductase1.1.1.211.000
1z3n3NAAldose reductase1.1.1.210.673
3g5eQ74Aldose reductase1.1.1.210.665
2i16LDTAldose reductase1.1.1.210.648
2fz8ZSTAldose reductase1.1.1.210.645
3ghuLDTAldose reductase1.1.1.210.640
3mb9ZSTAldose reductase1.1.1.210.637
2i17LDTAldose reductase1.1.1.210.635
2hvoZSTAldose reductase1.1.1.210.633
2dv0ZSTAldose reductase1.1.1.210.632
2hvnZSTAldose reductase1.1.1.210.631
2pdp393Aldose reductase1.1.1.210.628
3ghrLDTAldose reductase1.1.1.210.628
1pwlBFIAldose reductase1.1.1.210.626
2qxwLDTAldose reductase1.1.1.210.625
3ghsLDTAldose reductase1.1.1.210.620
2duxZSTAldose reductase1.1.1.210.619
2pd5ZSTAldose reductase1.1.1.210.619
1t40ID5Aldose reductase1.1.1.210.618
1us0LDTAldose reductase1.1.1.210.618
2hv5ZSTAldose reductase1.1.1.210.618
2pdxZSTAldose reductase1.1.1.210.617
2duzZSTAldose reductase1.1.1.210.616
2pdh47DAldose reductase1.1.1.210.609
3ld5LDTAldose reductase1.1.1.210.609
2fz9ZSTAldose reductase1.1.1.210.607
2pdu393Aldose reductase1.1.1.210.606
3ghtLDTAldose reductase1.1.1.210.606
2pdc393Aldose reductase1.1.1.210.604
2ikj393Aldose reductase1.1.1.210.598
3lboLDTAldose reductase1.1.1.210.596
3t423T4Aldose reductase1.1.1.210.593
2pdmZSTAldose reductase1.1.1.210.592
2pdbZSTAldose reductase1.1.1.210.589
2pdg47DAldose reductase1.1.1.210.589
2pdfZSTAldose reductase1.1.1.210.588
3lenZSTAldose reductase1.1.1.210.586
3mc5393Aldose reductase1.1.1.210.579
2iki388Aldose reductase1.1.1.210.578
3m64393Aldose reductase1.1.1.210.576
1z8962PAldose reductase1.1.1.210.574
2pdlTOLAldose reductase1.1.1.210.573
4gca2X9Aldose reductase1.1.1.210.573
4yu153NAldose reductase1.1.1.210.567
3m4h388Aldose reductase1.1.1.210.562
3lqlLDTAldose reductase1.1.1.210.561
1t41ID5Aldose reductase1.1.1.210.560
3m0iZSTAldose reductase1.1.1.210.559
2pdn47DAldose reductase1.1.1.210.556
1frbZSTAldose reductase-related protein 2/0.554
2pdiZSTAldose reductase1.1.1.210.551
3lz5LDTAldose reductase1.1.1.210.549
2fzdTOLAldose reductase1.1.1.210.534
1ieiZESAldose reductase1.1.1.210.533
2ikhLITAldose reductase1.1.1.210.531
2pdj393Aldose reductase1.1.1.210.531
1ah3TOLAldose reductase1.1.1.210.529
2pdq47DAldose reductase1.1.1.210.529
1zuaTOLAldo-keto reductase family 1 member B101.1.10.501
2f2kTGGAldose reductase1.1.1.210.493
2fzbTOLAldose reductase1.1.1.210.484
4e0u0MVCyclic dipeptide N-prenyltransferase/0.484
2agtFIDAldose reductase1.1.1.210.478
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.476
2pdyFIDAldose reductase1.1.1.210.473
2aot2PMHistamine N-methyltransferase2.1.1.80.471
2v0mKLNCytochrome P450 3A4/0.471
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.468
2iqdLPAAldose reductase1.1.1.210.466
2inzOHPAldose reductase1.1.1.210.461
1o5rFR9Adenosine deaminase3.5.4.40.460
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.456
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
1q83TZ5Acetylcholinesterase3.1.1.70.454
2ckmAA7Acetylcholinesterase3.1.1.70.454
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.454
2cekN8TAcetylcholinesterase3.1.1.70.453
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.453
4dbw511Aldo-keto reductase family 1 member C3/0.453
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.453
3f3y4OABile salt sulfotransferase2.8.2.140.452
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3s3gTLTAldose reductase1.1.1.210.451
2xujTZ5Acetylcholinesterase3.1.1.70.450
5stdUNNScytalone dehydratase4.2.1.940.450
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1h22E10Acetylcholinesterase3.1.1.70.448
1v7aFRCAdenosine deaminase3.5.4.40.448
2aovC2MHistamine N-methyltransferase2.1.1.80.448
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.448
3p2vDOYAldose reductase1.1.1.210.447
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.447
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.447
1ah0SBIAldose reductase1.1.1.210.446
1el3I84Aldose reductase1.1.1.210.446
1x8lOXRRetinol dehydratase/0.446
2j3qTFLAcetylcholinesterase3.1.1.70.446
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
1ef3FIDAldose reductase1.1.1.210.445
2xuhTZ4Acetylcholinesterase3.1.1.70.445
4gabFIDAldo-keto reductase family 1 member B101.1.10.445
5liu388Aldo-keto reductase family 1 member B101.1.10.444
2cbqTH2Neocarzinostatin/0.443
2ga2A19Methionine aminopeptidase 2/0.443
2xupTZ5Acetylcholinesterase3.1.1.70.443
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.443
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.443
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.442
3g72A6TRenin3.4.23.150.442
4dbuBT9Aldo-keto reductase family 1 member C3/0.442
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.442
4mt92D6Tankyrase-12.4.2.300.442
4phlPILPhosphodiesterase/0.442
2aouCQAHistamine N-methyltransferase2.1.1.80.441
2f3815MAldo-keto reductase family 1 member C3/0.441
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1zgcA2EAcetylcholinesterase3.1.1.70.440
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.440
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.440
5jqhCAUBeta-2 adrenergic receptor/0.440