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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pf8NDPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pf8NDPAldose reductase1.1.1.211.000
2pevNDPAldose reductase1.1.1.210.844
2iq0NAPAldose reductase1.1.1.210.708
2acqNAPAldose reductase1.1.1.210.691
1z8aNAPAldose reductase1.1.1.210.677
1az2NAPAldose reductase1.1.1.210.656
2pfhNDPAldose reductase1.1.1.210.656
1adsNAPAldose reductase1.1.1.210.653
1x98NAPAldose reductase1.1.1.210.653
3q65NAPAldose reductase1.1.1.210.632
2j8tNAPAldose reductase1.1.1.210.631
3q67NAPAldose reductase1.1.1.210.616
1ah4NAPAldose reductase1.1.1.210.614
2acuNAPAldose reductase1.1.1.210.609
1x96NAPAldose reductase1.1.1.210.603
3v36NAPAldose reductase1.1.1.210.597
3h7rNAPAldo-keto reductase family 4 member C8/0.591
2acsNAPAldose reductase1.1.1.210.583
1c9wNAPAldose reductase-related protein 2/0.572
3qkzNAPAldose reductase-related protein 11.1.1.210.572
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.569
3o3rNAPAldose reductase-related protein 11.1.1.210.568
4pmjNAPPutative oxidoreductase/0.567
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.559
2hejNDPAldo-keto reductase family 1 member C211.1.10.538
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.528
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.525
4xo7NAPAldo-keto reductase family 1 member C2/0.520
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.514
4g5dNDPProstaglandin F synthase1.1.1.1880.513
1zgdNAPChalcone reductase/0.512
4jtqNAPAldo-keto reductase family 1 member C2/0.511
1s1rNAPAldo-keto reductase family 1 member C3/0.509
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.509
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.509
5c7hNDPPutative oxidoreductase/0.504
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.503
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.501
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.499
2p5nNDPAldo-keto reductase family 1 member C211.1.10.499
1vp5NAPOxidoreductase, aldo/keto reductase family/0.498
2hdjNDPAldo-keto reductase family 1 member C2/0.497
4jq3NAPAldo-keto reductase family 1 member C2/0.497
4dz5NAPAldo-keto reductase family 1 member C3/0.495
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.494
1lqaNDPProtein tas/0.492
4l1xNAPAldo-keto reductase family 1 member C2/0.490
3wczNAPAldo-keto reductase AKR2E4/0.489
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.482
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.481
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.481
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.477
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.477
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.475
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.474
1z9aNADNAD(P)H-dependent D-xylose reductase1.1.1.3070.472
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.470
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.470
1pz1NAPGeneral stress protein 69/0.469
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.466
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.462
1ef3NAPAldose reductase1.1.1.210.453
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.452
2r9rNAPVoltage-gated potassium channel subunit beta-2/0.451
4jtdNAPVoltage-gated potassium channel subunit beta-2/0.451
1pz0NAPProtein IolS1.1.10.446
1ye6NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.441
2clpNDPAflatoxin B1 aldehyde reductase member 3/0.441