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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2pdp393Aldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2pdp393Aldose reductase1.1.1.211.000
1t41ID5Aldose reductase1.1.1.210.645
2fz9ZSTAldose reductase1.1.1.210.645
2pdxZSTAldose reductase1.1.1.210.643
1t40ID5Aldose reductase1.1.1.210.640
2dv0ZSTAldose reductase1.1.1.210.638
2hv5ZSTAldose reductase1.1.1.210.634
4gca2X9Aldose reductase1.1.1.210.631
1z3n3NAAldose reductase1.1.1.210.630
2pzn393Aldose reductase1.1.1.210.628
2pdc393Aldose reductase1.1.1.210.627
3g5eQ74Aldose reductase1.1.1.210.627
2fz8ZSTAldose reductase1.1.1.210.620
2pdmZSTAldose reductase1.1.1.210.620
3mb9ZSTAldose reductase1.1.1.210.620
3lenZSTAldose reductase1.1.1.210.618
2pd5ZSTAldose reductase1.1.1.210.617
1z8962PAldose reductase1.1.1.210.614
2pdu393Aldose reductase1.1.1.210.612
2iki388Aldose reductase1.1.1.210.611
2hvnZSTAldose reductase1.1.1.210.609
2qxwLDTAldose reductase1.1.1.210.609
3ghsLDTAldose reductase1.1.1.210.606
3ld5LDTAldose reductase1.1.1.210.604
3ghrLDTAldose reductase1.1.1.210.602
3t423T4Aldose reductase1.1.1.210.599
2duxZSTAldose reductase1.1.1.210.596
1pwlBFIAldose reductase1.1.1.210.595
1us0LDTAldose reductase1.1.1.210.595
2i16LDTAldose reductase1.1.1.210.593
1ieiZESAldose reductase1.1.1.210.591
3ghuLDTAldose reductase1.1.1.210.588
3ghtLDTAldose reductase1.1.1.210.587
2duzZSTAldose reductase1.1.1.210.586
2pdg47DAldose reductase1.1.1.210.586
2hvoZSTAldose reductase1.1.1.210.584
2i17LDTAldose reductase1.1.1.210.583
2pdbZSTAldose reductase1.1.1.210.583
3m0iZSTAldose reductase1.1.1.210.580
1frbZSTAldose reductase-related protein 2/0.577
2ikj393Aldose reductase1.1.1.210.577
3m64393Aldose reductase1.1.1.210.576
3m4h388Aldose reductase1.1.1.210.575
3lboLDTAldose reductase1.1.1.210.568
2pdh47DAldose reductase1.1.1.210.567
2pdj393Aldose reductase1.1.1.210.564
2ikhLITAldose reductase1.1.1.210.560
3mc5393Aldose reductase1.1.1.210.559
3lqlLDTAldose reductase1.1.1.210.557
2pdfZSTAldose reductase1.1.1.210.556
4yu153NAldose reductase1.1.1.210.555
2pdlTOLAldose reductase1.1.1.210.544
3lz5LDTAldose reductase1.1.1.210.540
2pdn47DAldose reductase1.1.1.210.531
2fzdTOLAldose reductase1.1.1.210.530
4phlPILPhosphodiesterase/0.490
1zuaTOLAldo-keto reductase family 1 member B101.1.10.489
1ah3TOLAldose reductase1.1.1.210.484
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.484
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.482
2f2kTGGAldose reductase1.1.1.210.482
2pdyFIDAldose reductase1.1.1.210.475
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
2iqdLPAAldose reductase1.1.1.210.468
3v94WYQPhosphodiesterase/0.468
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.466
4wevSUZAldo-keto reductase family 1 member B101.1.10.466
2aovC2MHistamine N-methyltransferase2.1.1.80.465
5liu388Aldo-keto reductase family 1 member B101.1.10.465
2agtFIDAldose reductase1.1.1.210.464
3n0hTOPDihydrofolate reductase1.5.1.30.464
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
3u2cSUZAldose reductase1.1.1.210.461
3s3gTLTAldose reductase1.1.1.210.460
4araC56Acetylcholinesterase3.1.1.70.460
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.457
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
2inzOHPAldose reductase1.1.1.210.454
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
1o6qR17Squalene--hopene cyclase4.2.1.1290.453
1ry0PG2Aldo-keto reductase family 1 member C3/0.452
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.452
4e0u0MVCyclic dipeptide N-prenyltransferase/0.452
3f3y4OABile salt sulfotransferase2.8.2.140.451
5d5aCAUBeta-2 adrenergic receptor/0.451
2pdwFIDAldose reductase1.1.1.210.450
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.449
1ef3FIDAldose reductase1.1.1.210.448
2f3815MAldo-keto reductase family 1 member C3/0.448
2w6cBM4Acetylcholinesterase3.1.1.70.448
2wzySQXSoluble acetylcholine receptor/0.448
3sn6P0GBeta-2 adrenergic receptor/0.448
2fzbTOLAldose reductase1.1.1.210.447
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.446
2tplHPPTyrosine phenol-lyase4.1.99.20.446
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2v0mKLNCytochrome P450 3A4/0.445
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.445
4msk2C8Tankyrase-12.4.2.300.445
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.444
1el3I84Aldose reductase1.1.1.210.443
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.443
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
4dbs0HVAldo-keto reductase family 1 member C3/0.442
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.441
2nvcITAAldose reductase1.1.1.210.441
3ojxFMNNADPH--cytochrome P450 reductase/0.441
3zkuHCVIsopenicillin N synthase1.21.3.10.441
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.441
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
2aot2PMHistamine N-methyltransferase2.1.1.80.440
2aouCQAHistamine N-methyltransferase2.1.1.80.440
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
4j7hTRHPCZA361.3/0.440