sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2o2m | LI0 | Bcl-2-like protein 1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2o2m | LI0 | Bcl-2-like protein 1 | / | 1.000 | |
| 3qkd | HI0 | Bcl-2-like protein 1 | / | 0.508 | |
| 3inq | X0J | Bcl-2-like protein 1 | / | 0.487 | |
| 3wiz | LC6 | Bcl-2-like protein 1 | / | 0.487 | |
| 3h23 | B54 | Dihydropteroate synthase | / | 0.482 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.471 | |
| 3lth | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.464 | |
| 5aqz | SGV | Heat shock 70 kDa protein 1A | / | 0.464 | |
| 3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.463 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.457 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.457 | |
| 3gwu | SRE | Na(+):neurotransmitter symporter (Snf family) | / | 0.455 | |
| 1kij | NOV | DNA gyrase subunit B | / | 0.454 | |
| 3fow | IMH | Purine nucleoside phosphorylase | / | 0.454 | |
| 1qk3 | 5GP | Hypoxanthine-guanine-xanthine phosphoribosyltransferase | 2.4.2.22 | 0.453 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.452 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 3hy4 | N5G | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 | 0.451 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.450 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.446 | |
| 2w5b | AGS | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.446 | |
| 1qtq | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.445 | |
| 4p5f | AR6 | Inosine-uridine nucleoside N-ribohydrolase | / | 0.445 | |
| 2bw7 | ECS | Adenylate cyclase | / | 0.444 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.443 | |
| 4jyz | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.443 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.443 | |
| 2ati | IHU | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.442 | |
| 2rjp | 886 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | 3.4.24.82 | 0.442 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.442 | |
| 3ewr | APR | Replicase polyprotein 1a | 3.4.22 | 0.441 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.441 | |
| 4kc2 | WS2 | Histo-blood group ABO system transferase | / | 0.441 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2b82 | ADN | Class B acid phosphatase | 3.1.3.2 | 0.440 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.440 |