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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.91.000
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.571
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.552
2v6oFADThioredoxin glutathione reductase/0.544
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.537
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.536
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.532
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.526
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.522
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.521
1greFADGlutathione reductase, mitochondrial1.8.1.70.517
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.515
1grhFADGlutathione reductase, mitochondrial1.8.1.70.507
3grsFADGlutathione reductase, mitochondrial1.8.1.70.506
1graFADGlutathione reductase, mitochondrial1.8.1.70.504
1grgFADGlutathione reductase, mitochondrial1.8.1.70.504
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.503
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.497
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.494
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.492
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.489
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.488
2r9zFADGlutathione amide reductase/0.483
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.479
1gerFADGlutathione reductase1.8.1.70.473
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.458
4j56FADThioredoxin reductase 21.8.1.90.457
1zx9FADMercuric reductase1.16.1.10.454
1zk7FADMercuric reductase1.16.1.10.451
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.448
1geuFADGlutathione reductase1.8.1.70.446
4nevFADTrypanothione reductase/0.446
1febFADTrypanothione reductase1.8.1.120.442
1grbFADGlutathione reductase, mitochondrial1.8.1.70.440
2rabFADGlutathione amide reductase/0.440