sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ikh | LIT | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.737 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.733 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.713 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.707 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.707 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.707 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.705 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.699 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.698 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.691 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.688 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.661 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.655 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.644 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.642 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.638 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.631 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.621 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.621 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.618 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.613 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.609 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.606 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.605 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.600 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.598 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.595 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.594 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.590 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.589 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.589 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.587 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.586 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.583 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.579 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.575 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.572 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.570 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.568 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.567 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.566 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.566 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.565 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.565 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.564 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.564 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.559 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.554 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.551 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.551 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.547 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.540 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.539 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.530 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.510 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.507 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.507 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.506 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.489 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.488 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.487 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.487 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.483 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.483 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.479 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.479 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.474 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.474 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.474 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.474 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.474 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.474 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.470 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.468 | |
| 1c7o | PPG | Hemolysin | / | 0.465 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.465 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.464 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.463 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.463 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.457 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.457 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.456 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.455 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.454 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.454 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.454 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.453 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.453 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.453 | |
| 4e32 | DWN | Methyltransferase | / | 0.453 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.453 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.452 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1fml | RTL | Retinol dehydratase | / | 0.450 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 4kmz | FOL | Folate receptor beta | / | 0.450 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.448 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.448 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.448 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.448 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.448 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.448 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.448 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.447 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.447 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.446 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.446 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.446 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.446 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.446 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.445 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.445 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1rxj | BNI | Streptavidin | / | 0.444 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.444 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4li7 | 1XP | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.444 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.443 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.443 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.443 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2e0i | FAD | DNA photolyase | / | 0.442 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.442 | |
| 2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.442 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 5a8e | XTK | Beta-1 adrenergic receptor | / | 0.442 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 2fhj | H4Z | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.441 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.441 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 4kn2 | LYA | Folate receptor beta | / | 0.441 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.441 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.440 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.440 |