sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2iiq | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2iiq | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 1.000 | |
| 2ii6 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.565 | |
| 2qs4 | LY5 | Glutamate receptor ionotropic, kainate 1 | / | 0.475 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.468 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.465 | |
| 2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.464 | |
| 2yyu | C5P | Orotidine 5'-phosphate decarboxylase | / | 0.455 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.455 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.453 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.452 | |
| 1qr2 | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.451 | |
| 4ddh | MS0 | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
| 1rp7 | TZD | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.449 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4b00 | I6X | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4b05 | 32D | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.446 | |
| 1n2h | PAJ | Pantothenate synthetase | 6.3.2.1 | 0.445 | |
| 3g5m | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.445 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 4jic | FMN | GTN Reductase | / | 0.443 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.442 | |
| 1lol | XMP | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.441 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.440 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.440 | |
| 3dm5 | GDP | Signal recognition particle 54 kDa protein | / | 0.440 | |
| 4a0r | DTB | Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial | 6.3.3.3 | 0.440 |