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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hs6FMN12-oxophytodienoate reductase 31.3.1.42

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hs6FMN12-oxophytodienoate reductase 31.3.1.421.000
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.644
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.636
1icpFMN12-oxophytodienoate reductase 11.3.1.420.606
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.606
1q45FMN12-oxophytodienoate reductase 31.3.1.420.581
3p62FMNPentaerythritol tetranitrate reductase/0.580
1icqFMN12-oxophytodienoate reductase 11.3.1.420.575
1icsFMN12-oxophytodienoate reductase 11.3.1.420.566
3p82FMNPentaerythritol tetranitrate reductase/0.566
4tmbFMNOld yellow enzyme/0.565
3hgrFMN12-oxophytodienoate reductase 11.3.1.420.557
1h50FMNPentaerythritol tetranitrate reductase/0.553
3f03FMNPentaerythritol tetranitrate reductase/0.553
3p74FMNPentaerythritol tetranitrate reductase/0.552
2abbFMNPentaerythritol tetranitrate reductase/0.551
1vjiFMN12-oxophytodienoate reductase 11.3.1.420.550
2q3rFMN12-oxophytodienoate reductase 11.3.1.420.550
1h51FMNPentaerythritol tetranitrate reductase/0.546
1h63FMNPentaerythritol tetranitrate reductase/0.542
2q3oFMN12-oxophytodienoate reductase 31.3.1.420.538
4rnuFMNNADPH dehydrogenase 11.6.99.10.537
4rnvFMNNADPH dehydrogenase 11.6.99.10.537
1vyrFMNPentaerythritol tetranitrate reductase/0.534
4rnwFMNNADPH dehydrogenase 11.6.99.10.524
3p67FMNPentaerythritol tetranitrate reductase/0.522
3gkaFMNN-ethylmaleimide reductase/0.512
4e2dFMNDehydrogenase/0.506
3atzFMNProstaglandin F2a synthase/0.502
4e2bFMNDehydrogenase/0.501
4jicFMNGTN Reductase/0.491
4df2FMNNADPH dehydrogenase/0.490
1bwlFMNNADPH dehydrogenase 11.6.99.10.489
3atyFMNProstaglandin F2a synthase/0.489
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.489
1o9bNAIQuinate/shikimate dehydrogenase/0.487
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.480
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.478
4uthFMNXenobiotic reductase/0.475
1xe55FEPlasmepsin-23.4.23.390.472
1z44FMNNADPH dehydrogenase/0.470
1bwkFMNNADPH dehydrogenase 11.6.99.10.468
4tmcFMNOld yellow enzyme/0.468
1bwsNDPGDP-L-fucose synthase/0.467
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.467
3p84FMNPentaerythritol tetranitrate reductase/0.466
5cfpC2EStimulator of interferon genes protein/0.464
1vi2NADQuinate/shikimate dehydrogenase/0.463
4q71FADBifunctional protein PutA/0.463
4qnwFMNChanoclavine-I aldehyde reductase easA/0.463
3ukoNADAlcohol dehydrogenase class-3/0.462
1s63778Protein farnesyltransferase subunit beta2.5.1.580.459
1x1aSAMC-20 methyltransferase/0.459
1yidATPTryptophan--tRNA ligase 26.1.1.20.459
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.458
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
3kruFMNNADH:flavin oxidoreductase/NADH oxidase/0.457
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.457
3l5lFMNXenobiotic reductase/0.456
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.456
1kbiFMNCytochrome b2, mitochondrial1.1.2.30.455
4wriOKAOkadaic acid binding protein 2-alpha/0.454
4h6kFMNNADPH dehydrogenase 11.6.99.10.453
4uymVOR14-alpha sterol demethylase Cyp51B/0.453
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
2g1n1IGRenin3.4.23.150.452
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.451
3p8jFMNPentaerythritol tetranitrate reductase/0.451
4eb5PLPCysteine desulfurase IscS 2/0.450
4loi1YCStimulator of interferon genes protein/0.450
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.449
3n19FNRXenobiotic reductase/0.449
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.449
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1lrjUD1UDP-glucose 4-epimerase5.1.3.20.448
2iyfERYOleandomycin glycosyltransferase2.4.10.448
3af1GDPPantothenate kinase2.7.1.330.448
4utkFNRXenobiotic reductase/0.447
1oyaFMNNADPH dehydrogenase 11.6.99.10.446
3tjlFMNNADPH dehydrogenase/0.446
3uylTYDProbable NDP-rhamnosyltransferase/0.444
4m5pFMNNADPH dehydrogenase/0.444
4xnw2IDP2Y purinoceptor 1/0.444
1k4mNADNicotinate-nucleotide adenylyltransferase2.7.7.180.443
2j07FADDeoxyribodipyrimidine photo-lyase4.1.99.30.443
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.443
4gddNAIUDP-galactopyranose mutase/0.443
3muoZPRProlyl endopeptidase/0.442
3rsv3RSBeta-secretase 13.4.23.460.442
4eb7PLPCysteine desulfurase IscS 2/0.442
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.441
3p8iFMNPentaerythritol tetranitrate reductase/0.441
2eixFADNADH-cytochrome b5 reductase/0.440
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.440
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.440