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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.643
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.630
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.628
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.617
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.616
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.608
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.604
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.600
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.597
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.595
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.592
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.591
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.588
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.586
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.580
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.579
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.576
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.574
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.574
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.567
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.559
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.558
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.555
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.551
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.551
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.546
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.542
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.538
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.534
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.534
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.530
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.526
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.524
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.521
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.521
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.509
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.508
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.508
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.508
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.506
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.502
4qnyANPMitogen activated protein kinase, putative/0.500
4j99ACPFibroblast growth factor receptor 2/0.496
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.494
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
4fv6E57Mitogen-activated protein kinase 12.7.11.240.492
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.482
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
3lltANPProtein serine/threonine kinase-1/0.479
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.478
3i60E86Mitogen-activated protein kinase 12.7.11.240.477
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.477
4j95ACPFibroblast growth factor receptor 2/0.476
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.474
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
3dfcANPDeath-associated protein kinase 12.7.11.10.473
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.473
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.473
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.150.473
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.470
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.469
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
1jklANPDeath-associated protein kinase 12.7.11.10.466
2uvzGVJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
1q24ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2y9qANPMitogen-activated protein kinase 12.7.11.240.463
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.463
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.462
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.461
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.460
4otiMI1Serine/threonine-protein kinase N1/0.460
3nieANPMitogen-activated protein kinase/0.459
4h3qANPMitogen-activated protein kinase 12.7.11.240.458
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
4nifANPMitogen-activated protein kinase 12.7.11.240.458
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.454
1qmzATPCyclin-dependent kinase 22.7.11.220.453
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.453
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.453
5av3KMPDeath-associated protein kinase 12.7.11.10.453
2ojj82AMitogen-activated protein kinase 12.7.11.240.452
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.452
2ijmADPFocal adhesion kinase 12.7.10.20.451
2yaaATPDeath-associated protein kinase 2/0.451
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.450
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.450
4ysjADPCalmodulin-like domain protein kinase/0.450
3ncz3NCRho-associated protein kinase 12.7.11.10.449
4e6d0NUTyrosine-protein kinase JAK2/0.449
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.448
4axdANPInositol-pentakisphosphate 2-kinase2.7.1.1580.447
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.446
5e8ySTUTGF-beta receptor type-22.7.11.300.446
4i5cC5ITyrosine-protein kinase JAK1/0.445
2j0lANPFocal adhesion kinase 12.7.10.20.444
4l9i8PRRhodopsin kinase/0.444
2f2uM77Rho-associated protein kinase 22.7.11.10.442
4aqc88ATyrosine-protein kinase JAK2/0.442
4eooATPCyclin-dependent kinase 22.7.11.220.442
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4ic7ANPMitogen-activated protein kinase 72.7.11.240.440
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.440
5av2KMPDeath-associated protein kinase 12.7.11.10.440