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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2fhyA37Fructose-1,6-bisphosphatase 13.1.3.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2fhyA37Fructose-1,6-bisphosphatase 13.1.3.111.000
2y5kYCUFructose-1,6-bisphosphatase 13.1.3.110.618
2wbdRO5Fructose-1,6-bisphosphatase 13.1.3.110.604
2wbbRO3Fructose-1,6-bisphosphatase 13.1.3.110.567
3b6zCO7Enoyl reductase LovC10.469
4g3jVNTLanosterol 14-alpha-demethylase/0.468
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.466
4dh60KNBeta-secretase 13.4.23.460.464
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.463
3gqvNAPEnoyl reductase LovC10.463
3syiFADSulfide-quinone reductase/0.463
1xe55FEPlasmepsin-23.4.23.390.462
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
1tj0FADBifunctional protein PutA1.5.5.20.461
1yb5NAPQuinone oxidoreductase1.6.5.50.461
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
2qfxNDPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.459
3b70NAPEnoyl reductase LovC10.459
4e5yNDPGDP-L-fucose synthase1.1.1.2710.459
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.458
4yaoFMNNADPH--cytochrome P450 reductase/0.457
3gw9VNILanosterol 14-alpha-demethylase/0.456
4nmdFDABifunctional protein PutA/0.456
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.456
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.455
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.453
4yryFADGlutamate synthase, beta subunit/0.453
1hxbROCGag-Pol polyprotein3.4.23.160.452
1ivp1ZKGag-Pol polyprotein/0.452
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.452
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.452
5ijzNAPNADP-specific glutamate dehydrogenase1.4.1.40.452
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.450
3uwlFOZThymidylate synthase/0.450
4ig01FGGag-Pol polyprotein2.7.7.490.450
1nqaNADGlyceraldehyde-3-phosphate dehydrogenase/0.449
2po7CHDFerrochelatase, mitochondrial4.99.1.10.449
3kc02T5Fructose-1,6-bisphosphatase 13.1.3.110.449
3zk5Z18Cytochrome P450 monooxygenase PikC/0.449
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.448
3ijoB4DGlutamate receptor 2/0.448
3kpkFADSulfide-quinone reductase/0.448
3u4cNDPNADPH-dependent reductase BacG/0.448
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.448
1ffuFADCarbon monoxide dehydrogenase medium chain/0.447
2z3uCRRCytochrome P450/0.447
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.447
3o3pGDDGlycosyl transferase, family 2/0.447
3wmxNADNAD dependent epimerase/dehydratase/0.447
1tj2FADBifunctional protein PutA1.5.5.20.446
3zuxTCHTransporter/0.446
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
4ku5DCC3-oxoacyl-[ACP] synthase III/0.446
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.445
3oxcROCProtease/0.445
3p4tFAOPutative acyl-CoA dehydrogenase/0.445
4kb9G79Protease/0.445
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.445
2vnaNAPProstaglandin reductase 21.3.1.480.444
3i2l2NCProtease/0.444
3lzs017Gag-Pol polyprotein3.4.23.160.444
3lzu017Gag-Pol polyprotein3.4.23.160.444
3poz03PEpidermal growth factor receptor2.7.10.10.444
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.444
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
4j6bPLOCytochrome P450 monooxygenase/0.444
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.444
4o8aFADBifunctional protein PutA1.2.1.880.444
1lbcCYZGlutamate receptor 2/0.443
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.443
3el4ROCGag-Pol polyprotein3.4.23.160.443
3q43D66M1 family aminopeptidase3.4.110.443
3sgtP09Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)/0.443
3t2zFADSulfide-quinone reductase/0.443
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.442
2qak1UNGag-Pol polyprotein3.4.23.160.442
3e2sFADBifunctional protein PutA1.5.5.20.442
3ndtROCGag-Pol polyprotein3.4.23.160.442
4j6cSTRCytochrome P450 monooxygenase/0.442
5hwsNAP2-dehydropantoate 2-reductase/0.442
2fy5SOPCholine O-acetyltransferase2.3.1.60.441
3oibFDAPutative acyl-CoA dehydrogenase/0.441
3sm2478Putative gag-pro-pol polyprotein/0.441
3sz0FADSulfide-quinone reductase/0.441
3w8wFADPutative FAD-dependent oxygenase EncM/0.441
5emhNAPIridoid synthase1.3.1.990.441
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.440
1xddAAYIntegrin alpha-L/0.440
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.440
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.440
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2p3b3TLV-1 PROTEASE protein/0.440
2p3b3TLV-1 protease/0.440
3d1yROCGag-Pol polyprotein3.4.23.160.440
3lpkZ76Beta-secretase 13.4.23.460.440
4q73FADBifunctional protein PutA/0.440