sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 1.000 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.628 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.482 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.472 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.464 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.464 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.461 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.460 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.459 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.454 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.454 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.453 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.449 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.447 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.446 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.445 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.445 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.444 | |
| 4jld | ADP | Adenylate kinase | / | 0.444 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.443 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.443 | |
| 2xfy | ACX | Beta-amylase | 3.2.1.2 | 0.443 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.442 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.441 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.441 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.440 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 |