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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2b9iADPMitogen-activated protein kinase FUS32.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2b9iADPMitogen-activated protein kinase FUS32.7.11.241.000
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.689
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.613
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.534
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.514
4qnyANPMitogen activated protein kinase, putative/0.508
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.499
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.497
1jstATPCyclin-dependent kinase 22.7.11.220.491
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.488
1qmzATPCyclin-dependent kinase 22.7.11.220.483
4ii5ADPCyclin-dependent kinase 22.7.11.220.482
4fmqANPMitogen-activated protein kinase 12.7.11.240.480
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.479
4xlvACPInsulin receptor2.7.10.10.478
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.477
4i3zADPCyclin-dependent kinase 22.7.11.220.476
4i5cC5ITyrosine-protein kinase JAK1/0.476
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.474
3zh8C58Protein kinase C iota type2.7.11.130.473
4ivb1J5Tyrosine-protein kinase JAK1/0.472
4fv6E57Mitogen-activated protein kinase 12.7.11.240.471
4h3qANPMitogen-activated protein kinase 12.7.11.240.471
4hge15VTyrosine-protein kinase JAK2/0.471
4nifANPMitogen-activated protein kinase 12.7.11.240.471
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.469
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.466
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.465
4btjADPTau-tubulin kinase 12.7.11.10.464
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.461
1i44ACPInsulin receptor2.7.10.10.458
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.456
2y9qANPMitogen-activated protein kinase 12.7.11.240.455
4btjATPTau-tubulin kinase 12.7.11.10.455
4aqc88ATyrosine-protein kinase JAK2/0.454
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.453
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.452
4ysjADPCalmodulin-like domain protein kinase/0.452
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.450
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.450
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.449
4oauADP2-5A-dependent ribonuclease3.1.260.449
3i60E86Mitogen-activated protein kinase 12.7.11.240.448
2pmlANPUncharacterized protein/0.447
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.447
1jnkANPMitogen-activated protein kinase 102.7.11.240.446
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.445
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.445
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.445
5e92ANPTGF-beta receptor type-22.7.11.300.445
3oroAGSSerine/threonine protein kinase/0.444
4eooATPCyclin-dependent kinase 22.7.11.220.444
1tvoFRZMitogen-activated protein kinase 12.7.11.240.443
1u4dDBQActivated CDC42 kinase 1/0.443
3nieANPMitogen-activated protein kinase/0.443
4ez50RSCyclin-dependent kinase 62.7.11.220.443
4fkv61KCyclin-dependent kinase 22.7.11.220.443
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
5cnnANPEpidermal growth factor receptor2.7.10.10.443
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.442
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.441
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.441
4ux9ANPMitogen-activated protein kinase 82.7.11.240.441
3lltANPProtein serine/threonine kinase-1/0.440