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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.41.000
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.619
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.605
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.577
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.574
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.570
3ladFADDihydrolipoyl dehydrogenase/0.556
3urhFADDihydrolipoyl dehydrogenase/0.550
2eq9FADDihydrolipoyl dehydrogenase/0.546
2yquFADDihydrolipoyl dehydrogenase/0.546
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.537
1zx9FADMercuric reductase1.16.1.10.529
4jq9FADDihydrolipoyl dehydrogenase/0.522
1zk7FADMercuric reductase1.16.1.10.519
2eq8FADDihydrolipoyl dehydrogenase/0.519
3ic9FADPutative dihydrolipoamide dehydrogenase/0.504
2r9zFADGlutathione amide reductase/0.503
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.500
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.487
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.484
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.483
3cgbFADCoenzyme A disulfide reductase/0.482
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.481
4ocgFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.477
3cgcFADCoenzyme A disulfide reductase/0.473
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.472
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.469
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.468
1zmdFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.463
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.463
1f8wFADNADH peroxidase1.11.1.10.462
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.462
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.457
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.456
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.455
2eq6FADDihydrolipoyl dehydrogenase/0.455
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.454
1nhpFADNADH peroxidase1.11.1.10.453
3lb8FADPutidaredoxin reductase1.18.1.50.453
2eq7FADDihydrolipoyl dehydrogenase/0.451
3grsFADGlutathione reductase, mitochondrial1.8.1.70.451
1grhFADGlutathione reductase, mitochondrial1.8.1.70.449
1xdiFADNAD(P)H dehydrogenase (quinone)/0.449
1gerFADGlutathione reductase1.8.1.70.447
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.447
1geuFADGlutathione reductase1.8.1.70.445
4j56FADThioredoxin reductase 21.8.1.90.444