scPDB - Distribution of Binding site Similarity values of 1uoo entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1uoo	GLY_PHE_ARG_PRO	Prolyl endopeptidase	3.4.21.26

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1uoo	GLY_PHE_ARG_PRO	Prolyl endopeptidase	3.4.21.26	1.000
1uop	GLY_PHE_GLU_PRO	Prolyl endopeptidase	3.4.21.26	0.743
1uoq	GLU_PHE_SER_PRO	Prolyl endopeptidase	3.4.21.26	0.638
3eq9	X97	Prolyl endopeptidase	3.4.21.26	0.637
1e8m	P0H	Prolyl endopeptidase	3.4.21.26	0.595
4bcd	TDV	Prolyl endopeptidase	3.4.21.26	0.569
3em0	CHD	Fatty acid-binding protein 6, ileal (gastrotropin)	/	0.506
1xdd	AAY	Integrin alpha-L	/	0.489
2ivn	ANP	tRNA N6-adenosine threonylcarbamoyltransferase	/	0.488
1qbq	HFP	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	/	0.477
1qbq	HFP	Protein farnesyltransferase subunit beta	2.5.1.58	0.477
2uxo	TAC	HTH-type transcriptional regulator TtgR	/	0.473
2rqf	JH3	Hemolymph juvenile hormone binding protein	/	0.471
1pqc	444	Oxysterols receptor LXR-beta	/	0.470
1pq9	44B	Oxysterols receptor LXR-beta	/	0.467
2b37	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.466
4iar	ERM	5-hydroxytryptamine receptor 1B	/	0.466
3ge6	FMN	Nitroreductase	/	0.465
4z63	ILE_THR_GLN_TYS_TYS	Phytosulfokine receptor 1	2.7.11.1	0.465
3u9f	CLM	Chloramphenicol acetyltransferase	2.3.1.28	0.463
2hwr	DRD	Peroxisome proliferator-activated receptor gamma	/	0.462
4iaq	2GM	5-hydroxytryptamine receptor 1B	/	0.460
4jzy	FAD	Cryptochrome-1	/	0.460
4wuo	NAD	3-isopropylmalate dehydrogenase	1.1.1.85	0.460
2vnj	FAD	NADPH:ferredoxin reductase	/	0.458
2xvi	FAD	Putative flavin-containing monooxygenase	/	0.458
2pob	GW4	Peroxisome proliferator-activated receptor gamma	/	0.457
2f4b	EHA	Peroxisome proliferator-activated receptor gamma	/	0.456
3dhe	AND	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.456
4e2y	JHZ	Methyltransferase	/	0.456
1q0r	AKT	Aclacinomycin methylesterase RdmC	3.1.1.95	0.455
1q0z	AKA	Aclacinomycin methylesterase RdmC	3.1.1.95	0.455
2po7	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.455
4kuh	CAA	3-hydroxybutyryl-CoA dehydrogenase	/	0.455
3nug	NAD	Pyridoxal 4-dehydrogenase	1.1.1.107	0.454
3dy8	5GP	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.453
3f1k	NAP	Uncharacterized oxidoreductase YciK	1	0.453
3bgx	MEF	Thymidylate synthase	/	0.452
4bby	FAD	Alkyldihydroxyacetonephosphate synthase, peroxisomal	2.5.1.26	0.452
4bfv	ZVV	Pantothenate kinase	2.7.1.33	0.452
4bfx	ZVX	Pantothenate kinase	2.7.1.33	0.452
4zgs	NAD	Putative D-lactate dehydrogenase	/	0.452
1nuu	NAD	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3	/	0.451
2y3r	TIR	TamL	/	0.451
3keu	ATP	Pyridoxal kinase	2.7.1.35	0.451
3mpi	FAD	Glutaryl-CoA dehydrogenase	1.3.99.32	0.451
4dri	RAP	Serine/threonine-protein kinase mTOR	2.7.11.1	0.451
4dri	RAP	Peptidyl-prolyl cis-trans isomerase FKBP5	5.2.1.8	0.451
1mxt	FAE	Cholesterol oxidase	1.1.3.6	0.450
2c20	NAD	UDP-glucose 4-epimerase	/	0.450
3dh7	FMN	Isopentenyl-diphosphate delta-isomerase	/	0.450
3eks	CY9	Actin-5C	/	0.450
3fhy	ATP	Pyridoxal kinase	2.7.1.35	0.450
4h8a	NAI	Ureidoglycolate dehydrogenase (NAD(+))	1.1.1.350	0.450
4z64	ILE_THR_GLN_TYS_TYS	Phytosulfokine receptor 1	2.7.11.1	0.450
1nuq	NXX	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3	/	0.449
2g1n	1IG	Renin	3.4.23.15	0.449
2vqb	FAD	Putative flavin-containing monooxygenase	/	0.449
2vbd	V10	Isopenicillin N synthase	1.21.3.1	0.448
2y3s	TIR	TamL	/	0.448
2yxu	ATP	Pyridoxal kinase	2.7.1.35	0.448
3cic	316	Beta-secretase 1	3.4.23.46	0.448
4bc7	FAD	Alkyldihydroxyacetonephosphate synthase, peroxisomal	2.5.1.26	0.448
1kkq	471	Peroxisome proliferator-activated receptor alpha	/	0.447
2rh9	IGP	Tryptophan synthase alpha chain	/	0.447
4fw8	NAI	3-oxoacyl-(Acyl-carrier-protein) reductase	/	0.447
4nbt	NAD	3-oxoacyl-[acyl-carrier-protein] reductase	/	0.447
1ea0	FMN	Glutamate synthase [NADPH] large chain	1.4.1.13	0.446
3b20	NAD	Glyceraldehyde-3-phosphate dehydrogenase	/	0.446
3d64	NAD	Adenosylhomocysteinase	/	0.446
3k3h	BYE	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.446
4g3j	VNT	Lanosterol 14-alpha-demethylase	/	0.446
4gxs	0YS	Glutamate receptor 2	/	0.446
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.445
2p9c	NAI	D-3-phosphoglycerate dehydrogenase	1.1.1.95	0.445
2vq7	FAD	Putative flavin-containing monooxygenase	/	0.444
3cmf	PDN	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.444
3dyl	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.444
3eku	CY9	Actin-5C	/	0.444
3ig6	438	Urokinase-type plasminogen activator	3.4.21.73	0.444
3iqh	TYR_ASP_ILE	Cysteine synthase	2.5.1.47	0.444
4ge9	0L0	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	2.6.1.39	0.444
1c7o	PPG	Hemolysin	/	0.443
1t2c	NAI	L-lactate dehydrogenase	1.1.1.27	0.443
3cid	318	Beta-secretase 1	3.4.23.46	0.443
3gw9	VNI	Lanosterol 14-alpha-demethylase	/	0.443
3k3e	PDB	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.443
3zbz	OVE	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.443
4bfz	ZVZ	Pantothenate kinase	2.7.1.33	0.443
4exg	916	Beta-secretase 1	3.4.23.46	0.443
4jnk	ZHK	L-lactate dehydrogenase A chain	1.1.1.27	0.443
5irn	ADP	Nucleotide binding oligomerization domain containing 2	/	0.443
1iqr	FAD	Deoxyribodipyrimidine photo-lyase	4.1.99.3	0.442
1qor	NDP	Quinone oxidoreductase 1	/	0.442
2gmh	FAD	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial	1.5.5.1	0.442
2i4j	DRJ	Peroxisome proliferator-activated receptor gamma	/	0.442
2iqg	F2I	Beta-secretase 1	3.4.23.46	0.442
4c7k	NAP	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.442
4d9f	DCS	D-cysteine desulfhydrase	/	0.442
4nie	NBH	Nuclear receptor ROR-gamma	/	0.442
1w0k	ADP	ATP synthase subunit alpha, mitochondrial	/	0.441
1w0k	ADP	ATP synthase subunit beta, mitochondrial	3.6.3.14	0.441
2bf4	FMN	NADPH--cytochrome P450 reductase	/	0.441
2c29	NAP	Dihydroflavonol 4-reductase	/	0.441
2owu	SAH	Diphthine synthase	/	0.441
2q5g	1FA	Peroxisome proliferator-activated receptor delta	/	0.441
2qbu	SAH	Precorrin-2 methyltransferase	/	0.441
2x86	ADP	ADP-L-glycero-D-manno-heptose-6-epimerase	/	0.441
2ztl	NAD	D(-)-3-hydroxybutyrate dehydrogenase	/	0.441
3duy	AFJ	Beta-secretase 1	3.4.23.46	0.441
4g2j	0WF	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.441
1k7f	IAV	Tryptophan synthase alpha chain	/	0.440
2nnl	NAP	Dihydroflavonol 4-reductase	1.1.1.219	0.440
2y6f	M9F	Isopenicillin N synthase	1.21.3.1	0.440
3dv3	MEK	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.440
3f6s	FMN	Flavodoxin	/	0.440
3ruh	NAD	UDP-N-acetylglucosamine 4-epimerase	/	0.440
3uoy	FAD	2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase	1.14.13.160	0.440
3up0	D7S	aceDAF-12	/	0.440
4f9m	FCM	Peroxisome proliferator-activated receptor gamma	/	0.440
4ysj	ADP	Calmodulin-like domain protein kinase	/	0.440
5dbj	FAD	FADH2-dependent halogenase PltA	/	0.440
5kwv	ANP	Pantothenate synthetase	/	0.440