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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1typFADTrypanothione reductase1.8.1.12

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1typFADTrypanothione reductase1.8.1.121.000
1greFADGlutathione reductase, mitochondrial1.8.1.70.597
4dnaFADProbable glutathione reductase/0.596
2hqmFADGlutathione reductase1.8.1.70.595
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.592
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.588
2jk6FADTrypanothione reductase/0.586
1grhFADGlutathione reductase, mitochondrial1.8.1.70.585
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.583
1grgFADGlutathione reductase, mitochondrial1.8.1.70.577
2wbaFADTrypanothione reductase1.8.1.120.576
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.573
1febFADTrypanothione reductase1.8.1.120.572
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.572
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.571
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.570
2v6oFADThioredoxin glutathione reductase/0.568
4la1FADThioredoxin glutathione reductase/0.562
3grsFADGlutathione reductase, mitochondrial1.8.1.70.559
1fecFADTrypanothione reductase1.8.1.120.555
1tytFADTrypanothione reductase1.8.1.120.555
1bzlFADTrypanothione reductase1.8.1.120.554
4j56FADThioredoxin reductase 21.8.1.90.552
4nevFADTrypanothione reductase/0.546
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.90.542
1gxfFADTrypanothione reductase1.8.1.120.537
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.536
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.532
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.526
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.526
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.515
2wp5FADTrypanothione reductase/0.513
2r9zFADGlutathione amide reductase/0.510
2wowFADTrypanothione reductase/0.505
2w0hFADTrypanothione reductase/0.503
4jq9FADDihydrolipoyl dehydrogenase/0.498
5er0FADUncharacterized NAD(FAD)-dependent dehydrogenase/0.496
4j57FADThioredoxin reductase 21.8.1.90.491
2eq7FADDihydrolipoyl dehydrogenase/0.485
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.481
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.480
2eq8FADDihydrolipoyl dehydrogenase/0.478
4emwFADCoenzyme A disulfide reductase/0.478
2yquFADDihydrolipoyl dehydrogenase/0.477
2eq9FADDihydrolipoyl dehydrogenase/0.471
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.467
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.463
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.462
1zx9FADMercuric reductase1.16.1.10.461
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.461
1nhqFADNADH peroxidase1.11.1.10.460
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.459
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.459
4eqwFADCoenzyme A disulfide reductase/0.456
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.455
4em4FADCoenzyme A disulfide reductase/0.452
1yqzFADCoenzyme A disulfide reductase/0.450
1nhpFADNADH peroxidase1.11.1.10.449
3ladFADDihydrolipoyl dehydrogenase/0.443
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.442
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.442
4g6hFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.441
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.441
2eq6FADDihydrolipoyl dehydrogenase/0.440