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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1s9eADBGag-Pol polyprotein2.7.7.49

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1s9eADBGag-Pol polyprotein2.7.7.491.000
1s6qTPBGag-Pol polyprotein2.7.7.490.634
1hnvTBOGag-Pol polyprotein2.7.7.490.577
2ze2T27Gag-Pol polyprotein2.7.7.490.575
1tvrTB9Gag-Pol polyprotein2.7.7.490.556
2rf2MRXGag-Pol polyprotein2.7.7.490.556
4i2q1BTGag-Pol polyprotein2.7.7.490.552
1vruAAPGag-Pol polyprotein2.7.7.490.549
4i2pG73Gag-Pol polyprotein2.7.7.490.549
1ikvEFZGag-Pol polyprotein2.7.7.490.542
4id5T27Gag-Pol polyprotein2.7.7.490.542
1tl1H18Gag-Pol polyprotein2.7.7.490.540
2zd1T27Gag-Pol polyprotein2.7.7.490.539
3meeT27Gag-Pol polyprotein2.7.7.490.539
1tkzH16Gag-Pol polyprotein2.7.7.490.537
3m8qDJZGag-Pol polyprotein2.7.7.490.537
4kko1REGag-Pol polyprotein2.7.7.490.536
1tktH12Gag-Pol polyprotein2.7.7.490.534
1tl3H20Gag-Pol polyprotein2.7.7.490.534
1revTB9Gag-Pol polyprotein2.7.7.490.531
1eetBFUGag-Pol polyprotein2.7.7.490.530
3med65BGag-Pol polyprotein2.7.7.490.528
4g1qT27Gag-Pol polyprotein2.7.7.490.526
2vg7NNIGag-Pol polyprotein2.7.7.490.525
3megT27Gag-Pol polyprotein2.7.7.490.524
4ko0JLJGag-Pol polyprotein2.7.7.490.524
1c1bGCAGag-Pol polyprotein2.7.7.490.523
1ikwEFZGag-Pol polyprotein2.7.7.490.520
1s1wUC1Gag-Pol polyprotein2.7.7.490.520
1hpzAAPGag-Pol polyprotein2.7.7.490.519
1ikyMSDGag-Pol polyprotein2.7.7.490.518
3qlhT27Gag-Pol polyprotein2.7.7.490.518
1ikxPNUGag-Pol polyprotein2.7.7.490.514
3i0rRT3Gag-Pol polyprotein2.7.7.490.514
3nbpJGZGag-Pol polyprotein2.7.7.490.512
4ifvT27Gag-Pol polyprotein2.7.7.490.511
1hquHBYGag-Pol polyprotein2.7.7.490.510
2ban357Gag-Pol polyprotein2.7.7.490.509
3is9AC7Gag-Pol polyprotein2.7.7.490.508
1fk9EFZGag-Pol polyprotein2.7.7.490.507
1rt5UC2Gag-Pol polyprotein2.7.7.490.507
3irxUDRGag-Pol polyprotein2.7.7.490.507
1tkxGWBGag-Pol polyprotein2.7.7.490.506
3i0sRT7Gag-Pol polyprotein2.7.7.490.505
3ffi3OBGag-Pol polyprotein2.7.7.490.503
1rt4UC1Gag-Pol polyprotein2.7.7.490.498
2vg5NNCGag-Pol polyprotein2.7.7.490.497
3m8p65BGag-Pol polyprotein2.7.7.490.496
2opqHBQGag-Pol polyprotein2.7.7.490.495
4ig3T27Gag-Pol polyprotein2.7.7.490.494
1jlgUC1Gag-Pol polyprotein2.7.7.490.489
3mec65BGag-Pol polyprotein2.7.7.490.486
3lamKRPGag-Pol polyprotein2.7.7.490.484
5cyqT27Gag-Pol polyprotein2.7.7.490.481
4i7fNVEGag-Pol polyprotein2.7.7.490.480
1rt7UC4Gag-Pol polyprotein2.7.7.490.479
1rt2TNKGag-Pol polyprotein2.7.7.490.477
2hnzPC0Gag-Pol polyprotein2.7.7.490.474
2c3qGTXGlutathione S-transferase theta-12.5.1.180.473
1hniAAAGag-Pol polyprotein2.7.7.490.472
3dleGFAGag-Pol polyprotein2.7.7.490.470
2hndNVPGag-Pol polyprotein2.7.7.490.466
3lanKBTGag-Pol polyprotein2.7.7.490.464
3bgrT27Gag-Pol polyprotein2.7.7.490.463
1xqcAEJEstrogen receptor/0.460
2vu3LZECyclin-dependent kinase 22.7.11.220.459
3hx4ANPCalmodulin-domain protein kinase 1/0.457
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.456
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
2oppHBQGag-Pol polyprotein2.7.7.490.454
1db1VDXVitamin D3 receptor/0.453
1jlqSBNGag-Pol polyprotein2.7.7.490.453
4g1z0VPVitamin D3 receptor A/0.453
2ic3HBYGag-Pol polyprotein2.7.7.490.451
3vrwYS5Vitamin D3 receptor/0.451
1n83CLRNuclear receptor ROR-alpha/0.450
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
3zewSTUEphrin type-B receptor 42.7.10.10.449
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.448
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
2j7t274Serine/threonine-protein kinase 102.7.11.10.447
2pvnP63Casein kinase II subunit alpha2.7.11.10.447
4nc3ERM5-hydroxytryptamine receptor 2B/0.447
5e8wSTUTGF-beta receptor type-12.7.11.300.447
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
1j39UPGDNA beta-glucosyltransferase/0.446
3ruqADPChaperonin/0.446
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2hw1ANPKetohexokinase/0.445
1ep4S11Gag-Pol polyprotein2.7.7.490.444
3kpzZNEVitamin D3 receptor/0.444
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.444
1jpaANPEphrin type-B receptor 22.7.10.10.443
1ndeMONEstrogen receptor beta/0.443
1qxlFR8Adenosine deaminase3.5.4.40.443
2hw2RFPRifampin ADP-ribosyl transferase/0.443
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.443
3aw9NADNAD-dependent epimerase/dehydratase/0.443
1h1s4SPCyclin-dependent kinase 22.7.11.220.442
3cd57HI3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.442
3dmjGWEPol protein/0.442
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.442
3w0yDS4Vitamin D3 receptor/0.442
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1osvCHCBile acid receptor/0.441
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.441
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.441
4k2xFADPolyketide oxygenase/hydroxylase/0.441
1klmSPPGag-Pol polyprotein2.7.7.490.440
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4ib4ERM5-hydroxytryptamine receptor 2B/0.440
4n6bCOAUncharacterized protein/0.440
4pd6URINucleoside permease/0.440