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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1s07PLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.62

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1s07PLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.621.000
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.572
1mlzPLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.505
4c13UMLUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase/0.490
4zwmPLPOrnithine aminotransferase, mitochondrial, putative/0.484
2oatPFMOrnithine aminotransferase, mitochondrial2.6.1.130.483
4ao4PLKBeta-transaminase/0.472
2xfsJ01Uncharacterized protein/0.470
2x3jATPAcsD/0.464
1xddAAYIntegrin alpha-L/0.463
1h73ANPHomoserine kinase2.7.1.390.458
3tjzGNPADP-ribosylation factor 1/0.456
2ffqGSPRas-related protein Rab-6B/0.455
4eb5PLPCysteine desulfurase IscS 2/0.455
1sb1165Prothrombin3.4.21.50.452
2iyfERYOleandomycin glycosyltransferase2.4.10.452
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.452
4n9iPCGCatabolite expression activator/0.452
1glfADPGlycerol kinase/0.451
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.451
3r9iADPSeptum site-determining protein MinD/0.451
3zkyWT4Isopenicillin N synthase1.21.3.10.451
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.451
2eudGCQRibonucleoside-diphosphate reductase large chain 11.17.4.10.450
3muoZPRProlyl endopeptidase/0.447
1daaPLPD-alanine aminotransferase2.6.1.210.446
1vjtNADAlpha-glucosidase, putative/0.446
2zsaADPPantothenate kinase2.7.1.330.446
3qt62P0Mevalonate diphosphate decarboxylase/0.446
2briANPUridylate kinase2.7.4.220.445
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.445
3oesGNPGTPase RhebL1/0.444
2flhZEACytokinin-specific binding protein/0.443
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.443
2gv8NDPThiol-specific monooxygenase1.14.130.442
2qjoNADBifunctional NMN adenylyltransferase/Nudix hydrolase2.7.7.10.442
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.442
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.442
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
4j7hTRHPCZA361.3/0.442
3imgBZ3Pantothenate synthetase6.3.2.10.441
3ty3GGGHomoisocitrate dehydrogenase1.1.1.870.440
5ah5LSSLeucine--tRNA ligase/0.440