scPDB - Distribution of Binding site Similarity values of 1rx4 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1rx4	DDF	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1rx4	DDF	Dihydrofolate reductase	1.5.1.3	1.000
1rx5	DDF	Dihydrofolate reductase	1.5.1.3	0.691
1rx7	FOL	Dihydrofolate reductase	1.5.1.3	0.680
1rx6	DDF	Dihydrofolate reductase	1.5.1.3	0.663
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.630
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.597
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.588
4i13	FOL	Dihydrofolate reductase	1.5.1.3	0.586
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.558
1jom	FFO	Dihydrofolate reductase	1.5.1.3	0.549
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.541
4i1n	FOL	Dihydrofolate reductase	1.5.1.3	0.540
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.539
5hi6	MTX	Dihydrofolate reductase	/	0.535
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.530
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.529
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.522
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.520
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.520
2d0k	FOL	Dihydrofolate reductase	1.5.1.3	0.519
4x5i	FOL	Dihydrofolate reductase	1.5.1.3	0.519
4qi9	MTX	Dihydrofolate reductase	/	0.518
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.515
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.510
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.503
5cc9	DDF	Dihydrofolate reductase	1.5.1.3	0.498
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.496
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.494
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.494
1dyi	FOL	Dihydrofolate reductase	1.5.1.3	0.493
2cig	1DG	Dihydrofolate reductase	1.5.1.3	0.492
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.490
1rb2	FOL	Dihydrofolate reductase	1.5.1.3	0.489
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.489
1ra3	MTX	Dihydrofolate reductase	1.5.1.3	0.488
4x5h	FOL	Dihydrofolate reductase	1.5.1.3	0.487
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.485
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.484
1rx8	FOL	Dihydrofolate reductase	1.5.1.3	0.481
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.481
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.480
1ra8	FOL	Dihydrofolate reductase	1.5.1.3	0.479
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.479
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.478
2qk8	MTX	Dihydrofolate reductase	/	0.475
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.475
2oal	FAD	Flavin-dependent tryptophan halogenase RebH	1.14.19.9	0.473
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	0.472
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.472
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.471
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.471
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.468
1m9j	CLW	Nitric oxide synthase, endothelial	1.14.13.39	0.464
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.463
3ex8	AIF	Riboflavin biosynthesis protein RibD	1.1.1.193	0.462
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.460
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.460
1m9k	7NI	Nitric oxide synthase, endothelial	1.14.13.39	0.458
1qoq	IGP	Tryptophan synthase alpha chain	/	0.458
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.458
5iu8	6DZ	Adenosine receptor A2a	/	0.458
1rfq	LAR	Actin, alpha skeletal muscle	/	0.457
4ms1	381	Gamma-aminobutyric acid type B receptor subunit 1	/	0.457
1bzf	TMQ	Dihydrofolate reductase	1.5.1.3	0.454
1kij	NOV	DNA gyrase subunit B	/	0.454
4elb	34S	Dihydrofolate reductase	/	0.453
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.451
2j9l	ATP	H(+)/Cl(-) exchange transporter 5	/	0.451
4lwa	Q13	Nitric oxide synthase oxygenase	1.14.13.165	0.451
4h3j	10W	Beta-secretase 1	3.4.23.46	0.450
2f7x	4EA	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.449
2lfo	GCH	Fatty acid-binding protein, liver	/	0.449
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.449
3tda	PN0	Cytochrome P450 2D6	/	0.449
5bp9	SAH	Putative methyltransferase protein	/	0.449
4gmg	NAP	Yersiniabactin biosynthetic protein YbtU	/	0.448
1nce	CB3	Thymidylate synthase	/	0.447
1rg7	MTX	Dihydrofolate reductase	1.5.1.3	0.447
2acl	REA	Retinoic acid receptor RXR-alpha	/	0.446
3tm5	SFG	Uncharacterized protein	/	0.446
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.445
3p9t	TCL	Repressor	/	0.445
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.445
4kne	1CY	Dihydrofolate reductase	1.5.1.3	0.445
1u71	MXA	Dihydrofolate reductase	1.5.1.3	0.444
4fxy	0W2	Neurolysin, mitochondrial	3.4.24.16	0.444
2fhj	H4Z	Formylmethanofuran--tetrahydromethanopterin formyltransferase	2.3.1.101	0.443
2w9h	TOP	Dihydrofolate reductase	1.5.1.3	0.443
4i8v	BHF	Cytochrome P450 1A1	1.14.14.1	0.443
4x7w	MVI	Mycinamicin III 3''-O-methyltransferase	2.1.1.237	0.443
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.442
3h3q	H13	Collagen type IV alpha-3-binding protein	/	0.442
4xz3	COA	Acyl-CoA synthetase (NDP forming)	/	0.442
3bk2	U5P	Ribonuclease J	/	0.441
3zei	AWH	O-acetylserine sulfhydrylase	/	0.441
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.440
1r35	I58	Nitric oxide synthase, inducible	1.14.13.39	0.440
4j6b	PLO	Cytochrome P450 monooxygenase	/	0.440