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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1rwbNADGlucose 1-dehydrogenase1.1.1.47

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1rwbNADGlucose 1-dehydrogenase1.1.1.471.000
1geeNADGlucose 1-dehydrogenase1.1.1.470.608
1gcoNADGlucose 1-dehydrogenase1.1.1.470.605
1g6kNADGlucose 1-dehydrogenase1.1.1.470.604
1ae1NAPTropinone reductase 1/0.531
3toxNAPPutative oxidoreductase/0.521
5idwNAPShort-chain dehydrogenase/reductase SDR/0.519
1wntNAPL-xylulose reductase1.1.1.100.517
1ipeNDPTropinone reductase 21.1.1.2360.516
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.514
3vdqNAD3-hydroxybutyrate dehydrogenase/0.514
4j7xNAPSepiapterin reductase1.1.1.1530.513
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.508
1x7hNDPPutative ketoacyl reductase1.3.10.508
3p19NDPPutative blue fluorescent protein/0.508
4hwkNAPSepiapterin reductase1.1.1.1530.508
4j7uNAPSepiapterin reductase1.1.1.1530.507
1x7gNAPPutative ketoacyl reductase1.3.10.505
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.505
1pr9NAPL-xylulose reductase1.1.1.100.504
1xg5NAPDehydrogenase/reductase SDR family member 11/0.504
2dteNAIGlucose 1-dehydrogenase related protein/0.504
2wdzNADGalactitol dehydrogenase/0.504
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.503
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.503
2bd0NAPSepiapterin reductase/0.500
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.498
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.495
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.494
3tn7NJPShort-chain alcohol dehydrogenase/0.493
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.491
3l77NJPShort-chain alcohol dehydrogenase/0.489
1n5dNDPCarbonyl reductase [NADPH] 1/0.488
1oaaNAPSepiapterin reductase1.1.1.1530.487
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.486
1w4zNAPPutative ketoacyl reductase1.3.10.485
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.485
4yaiNAIC alpha-dehydrogenase/0.485
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.484
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.484
1xkqNDPUncharacterized protein/0.483
3qrwNDPPutative ketoacyl reductase1.3.10.482
3wdsNADNADH-dependent quinuclidinone reductase/0.482
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.480
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.480
2wsbNADGalactitol dehydrogenase/0.480
3bmoNAPPteridine reductase/0.480
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.480
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.479
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.479
3w8eNAD3-hydroxybutyrate dehydrogenase/0.479
4dc1NDPPutative ketoacyl reductase1.3.10.479
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.478
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.478
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.478
4gh5NADShort-chain dehydrogenase/reductase SDR/0.478
1snyNAPLD36273p/0.477
4esoNAPPutative oxidoreductase/0.477
3gy0NAPNAD(P)-dependent oxidoreductase/0.474
4nbwNADShort-chain dehydrogenase/reductase SDR/0.472
5jlaNADPutative short-chain dehydrogenase/reductase/0.472
4yagNAIC alpha-dehydrogenase/0.470
3d3wNAPL-xylulose reductase1.1.1.100.468
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.468
2jahNDPClavaldehyde dehydrogenase/0.466
3f1kNAPUncharacterized oxidoreductase YciK10.465
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.464
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.464
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.463
3lqfNADGalactitol dehydrogenase/0.462
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.462
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.461
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.461
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.461
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.461
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.460
3sjuNDPKeto reductase/0.460
1iy8NADLevodione reductase/0.459
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.459
3w8dNAD3-hydroxybutyrate dehydrogenase/0.459
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.458
3ai2NDPNADPH-sorbose reductase/0.457
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.457
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.456
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.454
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.453
4fn4NADShort chain dehydrogenase/0.453
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.451
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.451
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.449
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.449
2yutNAPPutative short-chain oxidoreductase/0.449
4bmvNAPShort-chain dehydrogenase/0.449
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3ak4NADNADH-dependent quinuclidinone reductase/0.448
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.447
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.446
2ie0ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.445
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.443
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.442
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.442
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.440
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.440