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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1rtiHEFGag-Pol polyprotein2.7.7.49

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1rtiHEFGag-Pol polyprotein2.7.7.491.000
3dolGWIPol protein/0.616
3dmjGWEPol protein/0.615
3dlgGWEGag-Pol polyprotein2.7.7.490.607
3i0rRT3Gag-Pol polyprotein2.7.7.490.588
3e01PZ2Gag-Pol polyprotein2.7.7.490.587
3t195MAGag-Pol polyprotein2.7.7.490.574
4h4m494Gag-Pol polyprotein2.7.7.490.574
1rt1MKCGag-Pol polyprotein2.7.7.490.573
4mfb29TGag-Pol polyprotein2.7.7.490.568
1c1bGCAGag-Pol polyprotein2.7.7.490.567
3di6PDZGag-Pol polyprotein2.7.7.490.546
1jlaTNKGag-Pol polyprotein2.7.7.490.544
1s1vTNKGag-Pol polyprotein2.7.7.490.544
3c6uM22Gag-Pol polyprotein2.7.7.490.543
3dyaPZLGag-Pol polyprotein2.7.7.490.543
1rt2TNKGag-Pol polyprotein2.7.7.490.542
3ffi3OBGag-Pol polyprotein2.7.7.490.534
1c1c612Gag-Pol polyprotein2.7.7.490.529
3dokGWJPol protein/0.526
4i7fNVEGag-Pol polyprotein2.7.7.490.526
4rw6494Gag-Pol polyprotein2.7.7.490.526
3drpR8EGag-Pol polyprotein2.7.7.490.525
3drrR8EGag-Pol polyprotein2.7.7.490.524
3t1a5MAGag-Pol polyprotein2.7.7.490.524
3i0sRT7Gag-Pol polyprotein2.7.7.490.519
2be2R22Gag-Pol polyprotein2.7.7.490.518
2wonZZEGag-Pol polyprotein2.7.7.490.514
3lamKRPGag-Pol polyprotein2.7.7.490.511
3c6tM14Gag-Pol polyprotein2.7.7.490.510
3dleGFAGag-Pol polyprotein2.7.7.490.509
2ic3HBYGag-Pol polyprotein2.7.7.490.501
1hpzAAPGag-Pol polyprotein2.7.7.490.498
2b5j3ACGag-Pol polyprotein2.7.7.490.498
4rw4494Gag-Pol polyprotein2.7.7.490.498
3lanKBTGag-Pol polyprotein2.7.7.490.496
2rkiTT1Gag-Pol polyprotein2.7.7.490.495
1klmSPPGag-Pol polyprotein2.7.7.490.494
2ynhEURGag-Pol polyprotein2.7.7.490.493
1tvrTB9Gag-Pol polyprotein2.7.7.490.482
3nbpJGZGag-Pol polyprotein2.7.7.490.482
2ynfWHUGag-Pol polyprotein2.7.7.490.481
1ep4S11Gag-Pol polyprotein2.7.7.490.480
1x8lOXRRetinol dehydratase/0.475
1hquHBYGag-Pol polyprotein2.7.7.490.473
3t8xT8XT-cell surface glycoprotein CD1b/0.470
3is9AC7Gag-Pol polyprotein2.7.7.490.469
3lalKRVGag-Pol polyprotein2.7.7.490.468
1pq6965Oxysterols receptor LXR-beta/0.467
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.467
4a83DXCMajor pollen allergen Bet v 1-A/0.466
1yc2NADNAD-dependent protein deacylase 2/0.463
4b13NHWGlycylpeptide N-tetradecanoyltransferase/0.463
5cyqT27Gag-Pol polyprotein2.7.7.490.463
4b10NHWGlycylpeptide N-tetradecanoyltransferase/0.462
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.462
3tamM06Gag-Pol polyprotein2.7.7.490.461
1fmjRTLRetinol dehydratase/0.460
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.460
4a81DXCMajor pollen allergen Bet v 1-A/0.458
3kpkFADSulfide-quinone reductase/0.457
4iq71G9Mycocyclosin synthase1.14.21.90.457
2yneNHWGlycylpeptide N-tetradecanoyltransferase/0.456
5kf1ACOPredicted acetyltransferase/0.456
1fmlRTLRetinol dehydratase/0.455
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.454
4a87NARMajor pollen allergen Bet v 1-A/0.454
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.454
1bk0ACVIsopenicillin N synthase1.21.3.10.453
1obnASVIsopenicillin N synthase1.21.3.10.451
3p99LNPLanosterol 14-alpha-demethylase/0.451
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.451
1tl7FOKAdenylate cyclase type 2/0.450
1tl7FOKAdenylate cyclase type 5/0.450
2vu3LZECyclin-dependent kinase 22.7.11.220.450
5a27MYAGlycylpeptide N-tetradecanoyltransferase/0.450
1k7l544Peroxisome proliferator-activated receptor alpha/0.449
2jb4A14Isopenicillin N synthase1.21.3.10.449
2vcmM11Isopenicillin N synthase1.21.3.10.449
3stv3HOMethylketone synthase I/0.449
4b14NHWGlycylpeptide N-tetradecanoyltransferase/0.449
3sn6P0GBeta-2 adrenergic receptor/0.448
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.447
3irxUDRGag-Pol polyprotein2.7.7.490.447
3zoiM2WIsopenicillin N synthase1.21.3.10.447
4jlk1NODeoxycytidine kinase2.7.1.740.447
4ruoBIVVitamin D3 receptor A/0.447
1iyzNDPProbable quinone oxidoreductase/0.446
1xuoLA1Integrin alpha-L/0.445
2hnzPC0Gag-Pol polyprotein2.7.7.490.445
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.445
3p6oETGCamphor 5-monooxygenase1.14.15.10.445
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.445
5ag6MYAGlycylpeptide N-tetradecanoyltransferase/0.445
5k2bZMAAdenosine receptor A2a/0.445
3dl9V2HVitamin D 25-hydroxylase/0.444
4a4wYFBPeroxisome proliferator-activated receptor gamma/0.444
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.444
1rt7UC4Gag-Pol polyprotein2.7.7.490.443
4iaq2GM5-hydroxytryptamine receptor 1B/0.443
4jlj1NMDeoxycytidine kinase2.7.1.740.443
2w98P1ZProstaglandin reductase 21.3.1.480.442
2y60M8FIsopenicillin N synthase1.21.3.10.442
1uzwCDHIsopenicillin N synthase1.21.3.10.441
2yiuSMACytochrome b/0.441
1ykdCMPAdenylate cyclase/0.440
4iarERM5-hydroxytryptamine receptor 1B/0.440