sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1q4g | BFL | Prostaglandin G/H synthase 1 | 1.14.99.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1q4g | BFL | Prostaglandin G/H synthase 1 | 1.14.99.1 | 1.000 | |
| 1eqh | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.673 | |
| 1eqg | IBP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.648 | |
| 3pgh | FLP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.632 | |
| 4fm5 | DF0 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.625 | |
| 4rrx | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.622 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.621 | |
| 3n8x | NIM | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.617 | |
| 1ht8 | 34C | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.611 | |
| 3n8w | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.605 | |
| 4ph9 | IBP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.602 | |
| 3ntg | D72 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.601 | |
| 3rr3 | FLR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.585 | |
| 3n8z | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.584 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.574 | |
| 5ikr | ID8 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.565 | |
| 3ln1 | CEL | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.564 | |
| 4cox | IMN | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.563 | |
| 2ayl | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.562 | |
| 2oyu | IMS | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.541 | |
| 3q7d | NPX | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.535 | |
| 4rrw | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.524 | |
| 4rrz | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.524 | |
| 6cox | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.519 | |
| 4oty | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.516 | |
| 3kk6 | CEL | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.514 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.490 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.489 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.482 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.478 | |
| 3n8y | DIF | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.477 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.471 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 5ikq | JMS | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.463 | |
| 3ln0 | 52B | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.461 | |
| 4hia | FMN | LOV protein | / | 0.461 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.461 | |
| 4iae | 1DX | Alr2278 protein | / | 0.459 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.453 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.453 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.452 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.451 | |
| 1hsg | MK1 | Gag-Pol polyprotein | / | 0.450 | |
| 1ht5 | FL2 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.450 | |
| 3o9i | A61 | Gag-Pol polyprotein | / | 0.450 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.448 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1wlv | COA | Phenylacetic acid degradation protein PaaI | / | 0.446 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 3kfr | 3TL | Gag-Pol polyprotein | / | 0.446 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4eaj | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.446 | |
| 4fgr | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.446 | |
| 1cx2 | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.445 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.445 | |
| 2bxi | AZQ | Serum albumin | / | 0.445 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.445 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4eet | FMN | Phototropin-2 | 2.7.11.1 | 0.445 | |
| 1p9w | ANP | Type II secretion system protein E | / | 0.444 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.444 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.444 | |
| 5c41 | ACP | Ribokinase | / | 0.444 | |
| 5ikt | TLF | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.443 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.442 | |
| 3em4 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.442 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.442 | |
| 1gqt | ACP | Ribokinase | / | 0.441 | |
| 2avv | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2r5q | 1UN | Gag-Pol polyprotein | / | 0.441 | |
| 2rl2 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.441 | |
| 3qrm | NK7 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.441 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.440 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.440 |