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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1onfFADGlutathione reductase1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1onfFADGlutathione reductase1.8.1.71.000
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.495
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.482
2r9zFADGlutathione amide reductase/0.481
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.478
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.475
3grsFADGlutathione reductase, mitochondrial1.8.1.70.470
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.466
1zx9FADMercuric reductase1.16.1.10.465
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.463
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.462
1grhFADGlutathione reductase, mitochondrial1.8.1.70.460
2eq9FADDihydrolipoyl dehydrogenase/0.458
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.458
1graFADGlutathione reductase, mitochondrial1.8.1.70.457
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.457
1greFADGlutathione reductase, mitochondrial1.8.1.70.456
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.456
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.455
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.453
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.453
1zk7FADMercuric reductase1.16.1.10.451
1febFADTrypanothione reductase1.8.1.120.450
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.450
1grgFADGlutathione reductase, mitochondrial1.8.1.70.449
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.449
2rabFADGlutathione amide reductase/0.447
1gerFADGlutathione reductase1.8.1.70.444
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.444
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.442
4j56FADThioredoxin reductase 21.8.1.90.442
3djgFADGlutathione reductase, mitochondrial1.8.1.70.441
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.440