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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1n5dNDPCarbonyl reductase [NADPH] 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1n5dNDPCarbonyl reductase [NADPH] 1/1.000
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.599
5idwNAPShort-chain dehydrogenase/reductase SDR/0.562
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.560
1snyNAPLD36273p/0.553
4j7xNAPSepiapterin reductase1.1.1.1530.542
4j7uNAPSepiapterin reductase1.1.1.1530.538
4hwkNAPSepiapterin reductase1.1.1.1530.524
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.511
4qecNAPElxO/0.510
1oaaNAPSepiapterin reductase1.1.1.1530.509
1ae1NAPTropinone reductase 1/0.506
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.504
1x7hNDPPutative ketoacyl reductase1.3.10.501
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.499
1ipeNDPTropinone reductase 21.1.1.2360.498
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.498
1x7gNAPPutative ketoacyl reductase1.3.10.497
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.497
2yutNAPPutative short-chain oxidoreductase/0.497
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.497
3toxNAPPutative oxidoreductase/0.492
1w4zNAPPutative ketoacyl reductase1.3.10.491
2bd0NAPSepiapterin reductase/0.488
3qrwNDPPutative ketoacyl reductase1.3.10.488
4dc1NDPPutative ketoacyl reductase1.3.10.486
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.485
1pr9NAPL-xylulose reductase1.1.1.100.483
3gy0NAPNAD(P)-dependent oxidoreductase/0.482
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.482
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.480
4yaiNAIC alpha-dehydrogenase/0.480
1g6kNADGlucose 1-dehydrogenase1.1.1.470.479
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.479
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.479
4bmvNAPShort-chain dehydrogenase/0.479
2dteNAIGlucose 1-dehydrogenase related protein/0.478
3f1kNAPUncharacterized oxidoreductase YciK10.478
3p19NDPPutative blue fluorescent protein/0.478
5jlaNADPutative short-chain dehydrogenase/reductase/0.477
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.476
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.476
1xkqNDPUncharacterized protein/0.475
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.475
3w8eNAD3-hydroxybutyrate dehydrogenase/0.473
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.473
4impNDPPolyketide synthase extender modules 3-4/0.472
2jahNDPClavaldehyde dehydrogenase/0.471
3lqfNADGalactitol dehydrogenase/0.470
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.469
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.469
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.468
3l77NJPShort-chain alcohol dehydrogenase/0.467
1wntNAPL-xylulose reductase1.1.1.100.466
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.466
4qedNAPElxO/0.466
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.465
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.465
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.464
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.463
1xg5NAPDehydrogenase/reductase SDR family member 11/0.463
2wsbNADGalactitol dehydrogenase/0.462
3sjuNDPKeto reductase/0.462
3ak4NADNADH-dependent quinuclidinone reductase/0.461
3d3wNAPL-xylulose reductase1.1.1.100.461
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.460
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.458
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.457
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.455
1rwbNADGlucose 1-dehydrogenase1.1.1.470.455
3ai2NDPNADPH-sorbose reductase/0.455
2wdzNADGalactitol dehydrogenase/0.453
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.453
4yagNAIC alpha-dehydrogenase/0.453
3tn7NJPShort-chain alcohol dehydrogenase/0.452
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.452
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.450
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.448
3vdqNAD3-hydroxybutyrate dehydrogenase/0.448
4esoNAPPutative oxidoreductase/0.447
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.447
4jbiNDPAlcohol dehydrogenase (Zinc)/0.445
5lc1NADL-threonine 3-dehydrogenase/0.445
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.444
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.443
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.443
1iy8NADLevodione reductase/0.442
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.442
3w8dNAD3-hydroxybutyrate dehydrogenase/0.442
3rj9NADAlcohol dehydrogenase1.1.1.10.441
2v6gNAP3-oxo-Delta(4,5)-steroid 5-beta-reductase/0.440