sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 1.000 | |
| 1gil | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.707 | |
| 1azt | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.593 | |
| 3c16 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.560 | |
| 4pao | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.550 | |
| 3c14 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.546 | |
| 1got | GDP | Guanine nucleotide-binding protein G(t) subunit alpha-1 | / | 0.537 | |
| 1cul | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.535 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.535 | |
| 1cs4 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.531 | |
| 1u0h | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.516 | |
| 3c15 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.506 | |
| 2gvd | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.502 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.502 | |
| 4fid | GDP | G protein alpha subunit, putative | / | 0.499 | |
| 3qe0 | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.498 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.497 | |
| 1y3a | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.487 | |
| 3r7w | GNP | GTP-binding protein GTR2 | / | 0.487 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.476 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.476 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.474 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.469 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.462 | |
| 3cx6 | GDP | Guanine nucleotide-binding protein subunit alpha-13 | / | 0.461 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.459 | |
| 5doz | NDP | JamJ | / | 0.458 | |
| 3mjh | GTP | Ras-related protein Rab-5A | / | 0.457 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.454 | |
| 1okk | GCP | Signal recognition particle protein | / | 0.452 | |
| 1okk | GCP | Signal recognition particle receptor FtsY | / | 0.452 | |
| 1ky2 | GNP | GTP-binding protein YPT7 | / | 0.451 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.451 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.450 | |
| 1jq5 | NAD | Glycerol dehydrogenase | 1.1.1.6 | 0.449 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.449 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.449 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.449 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.448 | |
| 1gp2 | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.447 | |
| 1iy8 | NAD | Levodione reductase | / | 0.447 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.447 | |
| 2fg5 | GNP | Ras-related protein Rab-31 | / | 0.446 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.446 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.446 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.446 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.445 | |
| 2eu8 | AP5 | Adenylate kinase | / | 0.445 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.445 | |
| 3w6u | NAP | 6-phosphogluconate dehydrogenase, NAD-binding protein | / | 0.445 | |
| 5l3r | GCP | Cell division protein FtsY homolog, chloroplastic | / | 0.445 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.444 | |
| 3sgl | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.444 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.444 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.443 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.443 | |
| 5kcz | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.442 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.442 | |
| 4uj3 | GNP | Ras-related protein Rab-11A | / | 0.442 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.441 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.441 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.441 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.441 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.441 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.440 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.440 | |
| 4ijr | NDP | D-arabinose dehydrogenase [NAD(P)+] heavy chain | 1.1.1.117 | 0.440 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.440 |