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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1gcoNADGlucose 1-dehydrogenase1.1.1.47

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1gcoNADGlucose 1-dehydrogenase1.1.1.471.000
1geeNADGlucose 1-dehydrogenase1.1.1.470.879
1g6kNADGlucose 1-dehydrogenase1.1.1.470.598
1rwbNADGlucose 1-dehydrogenase1.1.1.470.589
3p19NDPPutative blue fluorescent protein/0.539
3toxNAPPutative oxidoreductase/0.531
5jlaNADPutative short-chain dehydrogenase/reductase/0.517
1x7gNAPPutative ketoacyl reductase1.3.10.515
3vdqNAD3-hydroxybutyrate dehydrogenase/0.515
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.514
1w4zNAPPutative ketoacyl reductase1.3.10.513
3w8eNAD3-hydroxybutyrate dehydrogenase/0.507
2wdzNADGalactitol dehydrogenase/0.504
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.504
4j7uNAPSepiapterin reductase1.1.1.1530.504
4j7xNAPSepiapterin reductase1.1.1.1530.504
1x7hNDPPutative ketoacyl reductase1.3.10.502
4b79NADProbable short-chain dehydrogenase/0.500
1ipeNDPTropinone reductase 21.1.1.2360.499
4hwkNAPSepiapterin reductase1.1.1.1530.499
1wntNAPL-xylulose reductase1.1.1.100.494
1pr9NAPL-xylulose reductase1.1.1.100.493
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.493
5idwNAPShort-chain dehydrogenase/reductase SDR/0.493
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.492
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.492
3bmoNAPPteridine reductase/0.491
4dc1NDPPutative ketoacyl reductase1.3.10.491
2dteNAIGlucose 1-dehydrogenase related protein/0.490
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.489
3ai2NDPNADPH-sorbose reductase/0.488
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.487
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.487
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.484
2bd0NAPSepiapterin reductase/0.482
2jahNDPClavaldehyde dehydrogenase/0.482
1ae1NAPTropinone reductase 1/0.479
3d3wNAPL-xylulose reductase1.1.1.100.479
4yaiNAIC alpha-dehydrogenase/0.478
1snyNAPLD36273p/0.477
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.477
3w8dNAD3-hydroxybutyrate dehydrogenase/0.477
4yagNAIC alpha-dehydrogenase/0.477
1xg5NAPDehydrogenase/reductase SDR family member 11/0.476
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.476
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.476
3sjuNDPKeto reductase/0.476
3l77NJPShort-chain alcohol dehydrogenase/0.474
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.474
1oaaNAPSepiapterin reductase1.1.1.1530.473
1xkqNDPUncharacterized protein/0.473
3gy0NAPNAD(P)-dependent oxidoreductase/0.473
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.473
2wsbNADGalactitol dehydrogenase/0.472
3lqfNADGalactitol dehydrogenase/0.472
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.471
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.470
4esoNAPPutative oxidoreductase/0.470
4qecNAPElxO/0.469
3qrwNDPPutative ketoacyl reductase1.3.10.468
1qyvNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.467
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.467
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.467
4gh5NADShort-chain dehydrogenase/reductase SDR/0.467
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.465
3w8fNAD3-hydroxybutyrate dehydrogenase/0.465
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.464
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.463
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.463
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.462
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.462
3wdsNADNADH-dependent quinuclidinone reductase/0.462
4bmvNAPShort-chain dehydrogenase/0.462
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.462
2p5uNADUDP-glucose 4-epimerase/0.461
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.461
1iy8NADLevodione reductase/0.460
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.460
3ai3NDPNADPH-sorbose reductase/0.460
3ak4NADNADH-dependent quinuclidinone reductase/0.460
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.459
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.459
3f1kNAPUncharacterized oxidoreductase YciK10.458
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.458
1zemNADXylitol dehydrogenase/0.457
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.456
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.455
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.455
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.455
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.455
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.454
2yutNAPPutative short-chain oxidoreductase/0.454
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.454
1n5dNDPCarbonyl reductase [NADPH] 1/0.453
4fn4NADShort chain dehydrogenase/0.453
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.452
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.451
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.449
5jydNADShort chain dehydrogenase/0.449
1rkxNADCDP-D-glucose-4,6-dehydratase/0.448
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.448
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.448
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.447
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.447
4q71FADBifunctional protein PutA/0.447
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3tn7NJPShort-chain alcohol dehydrogenase/0.446
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.445
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.445
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
3autNAIGlucose 1-dehydrogenase 41.1.1.470.444
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1nytNAPShikimate dehydrogenase (NADP(+))/0.443
3uxyNADShort-chain dehydrogenase/reductase SDR/0.443
4nbwNADShort-chain dehydrogenase/reductase SDR/0.443
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.442
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.441
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.441
2bfoNDPPteridine reductase 11.5.1.330.440