sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1g4t | FTP | Thiamine-phosphate synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1g4t | FTP | Thiamine-phosphate synthase | / | 1.000 | |
| 1g69 | TZP | Thiamine-phosphate synthase | / | 0.679 | |
| 1g6c | TZP | Thiamine-phosphate synthase | / | 0.636 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.636 | |
| 1g4s | TPS | Thiamine-phosphate synthase | / | 0.589 | |
| 1g67 | TZP | Thiamine-phosphate synthase | / | 0.588 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.526 | |
| 1g6c | IFP | Thiamine-phosphate synthase | / | 0.501 | |
| 4nu5 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.486 | |
| 3o15 | 3NM | Thiamine-phosphate synthase | / | 0.472 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.471 | |
| 1hwz | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.467 | |
| 4e5k | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.466 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.463 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.460 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.457 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4e5n | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.456 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.455 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.454 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.454 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.452 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.452 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.449 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.449 | |
| 3ohf | 3HF | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.448 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4die | C5P | Cytidylate kinase | / | 0.448 | |
| 5ez7 | FAD | Probable FAD-dependent oxidoreductase PA4991 | / | 0.448 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.447 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.447 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1gqt | ACP | Ribokinase | / | 0.446 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.446 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.445 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.445 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.444 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.444 | |
| 3q8x | UD1 | Toxin zeta | / | 0.443 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3dl0 | AP5 | Adenylate kinase | / | 0.442 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.442 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.441 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.440 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.440 |