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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1finATPCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1finATPCyclin-dependent kinase 22.7.11.221.000
4bcmT7ZCyclin-dependent kinase 22.7.11.220.542
3tnwF18Cyclin-dependent kinase 22.7.11.220.511
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.507
1fvv107Cyclin-dependent kinase 22.7.11.220.506
2c4g514Cyclin-dependent kinase 22.7.11.220.492
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.489
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.484
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.479
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.479
4ii5ADPCyclin-dependent kinase 22.7.11.220.475
2vu3LZECyclin-dependent kinase 22.7.11.220.473
2i40BLZCyclin-dependent kinase 22.7.11.220.472
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.472
4ic7ANPMitogen-activated protein kinase 72.7.11.240.470
4j95ACPFibroblast growth factor receptor 2/0.470
4j97ACPFibroblast growth factor receptor 2/0.470
2vv9IM9Cyclin-dependent kinase 22.7.11.220.469
3c4xATPRhodopsin kinase/0.469
1pkdUCNCyclin-dependent kinase 22.7.11.220.468
2cjmATPCyclin-dependent kinase 22.7.11.220.468
2uzdC85Cyclin-dependent kinase 22.7.11.220.468
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.466
2j0lANPFocal adhesion kinase 12.7.10.20.463
2uzbC75Cyclin-dependent kinase 22.7.11.220.462
3nux3NVCyclin-dependent kinase 62.7.11.220.462
1pyePM1Cyclin-dependent kinase 22.7.11.220.461
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.461
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.461
4bcqTJFCyclin-dependent kinase 22.7.11.220.460
5ap7SVEDual specificity protein kinase TTK2.7.12.10.460
3nup3NUCyclin-dependent kinase 62.7.11.220.459
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.459
4l9i8PRRhodopsin kinase/0.459
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.458
2wpa889Cyclin-dependent kinase 22.7.11.220.458
2w05FRTCyclin-dependent kinase 22.7.11.220.456
3ezvEZVCyclin-dependent kinase 22.7.11.220.456
4j99ACPFibroblast growth factor receptor 2/0.456
1g5sI17Cyclin-dependent kinase 22.7.11.220.455
3rak03ZCyclin-dependent kinase 22.7.11.220.455
4qmlANPSerine/threonine-protein kinase 242.7.11.10.455
2hog710Serine/threonine-protein kinase Chk12.7.11.10.452
1e9hINRCyclin-dependent kinase 22.7.11.220.451
1p2a5BNCyclin-dependent kinase 22.7.11.220.451
4eooATPCyclin-dependent kinase 22.7.11.220.451
2cchATPCyclin-dependent kinase 22.7.11.220.450
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.450
3my5RFZCyclin-dependent kinase 22.7.11.220.449
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.449
3lltANPProtein serine/threonine kinase-1/0.448
3qxpX64Cyclin-dependent kinase 22.7.11.220.448
4aguD15Cyclin-dependent kinase-like 1/0.448
3i60E86Mitogen-activated protein kinase 12.7.11.240.447
4erwSTUCyclin-dependent kinase 22.7.11.220.447
3a7hATPSerine/threonine-protein kinase 242.7.11.10.446
2x6dX6DAurora kinase A2.7.11.10.445
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.445
4f640S8Fibroblast growth factor receptor 1/0.445
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.444
2c6lDT4Cyclin-dependent kinase 22.7.11.220.444
2ckeIQUDeath-associated protein kinase 2/0.444
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3begANPSRSF protein kinase 12.7.11.10.444
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.443
3c4wATPRhodopsin kinase/0.443
4eym0RXMitogen-activated protein kinase 132.7.11.240.443
4fx360KCyclin-dependent kinase 22.7.11.220.443
4i3zADPCyclin-dependent kinase 22.7.11.220.442
1ke6LS2Cyclin-dependent kinase 22.7.11.220.441
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.441
2wipP49Cyclin-dependent kinase 22.7.11.220.441
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.441
3s1h56ZCyclin-dependent kinase 22.7.11.220.441
2fvdLIACyclin-dependent kinase 22.7.11.220.440
2ijmADPFocal adhesion kinase 12.7.10.20.440
2vttLZDCyclin-dependent kinase 22.7.11.220.440
2wihP48Cyclin-dependent kinase 22.7.11.220.440
3r7uX96Cyclin-dependent kinase 22.7.11.220.440
4bbfO19Tyrosine-protein kinase JAK2/0.440
4gmy0X5Tyrosine-protein kinase JAK2/0.440