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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1febFADTrypanothione reductase1.8.1.12

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1febFADTrypanothione reductase1.8.1.121.000
1feaFADTrypanothione reductase1.8.1.120.573
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.569
1bzlFADTrypanothione reductase1.8.1.120.562
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.562
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.559
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.553
1gerFADGlutathione reductase1.8.1.70.551
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.550
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.542
1grhFADGlutathione reductase, mitochondrial1.8.1.70.540
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.540
1grgFADGlutathione reductase, mitochondrial1.8.1.70.535
2v6oFADThioredoxin glutathione reductase/0.534
3grsFADGlutathione reductase, mitochondrial1.8.1.70.532
1greFADGlutathione reductase, mitochondrial1.8.1.70.529
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.526
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.522
4nevFADTrypanothione reductase/0.522
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.520
4jq9FADDihydrolipoyl dehydrogenase/0.520
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.512
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.507
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.504
2r9zFADGlutathione amide reductase/0.504
1graFADGlutathione reductase, mitochondrial1.8.1.70.500
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.498
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.492
4j56FADThioredoxin reductase 21.8.1.90.486
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.485
1zx9FADMercuric reductase1.16.1.10.483
2eq9FADDihydrolipoyl dehydrogenase/0.477
3urhFADDihydrolipoyl dehydrogenase/0.477
1zk7FADMercuric reductase1.16.1.10.472
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.471
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.470
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.470
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.463
2yquFADDihydrolipoyl dehydrogenase/0.461
4dnaFADProbable glutathione reductase/0.459
1onfFADGlutathione reductase1.8.1.70.458
2eq8FADDihydrolipoyl dehydrogenase/0.458
2hqmFADGlutathione reductase1.8.1.70.454
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.451
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.450
3ladFADDihydrolipoyl dehydrogenase/0.449
3ic9FADPutative dihydrolipoamide dehydrogenase/0.448
1geuFADGlutathione reductase1.8.1.70.445
3ctyFADProbable thioredoxin reductase/0.442
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.440