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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ebdFADDihydrolipoyl dehydrogenase1.8.1.4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ebdFADDihydrolipoyl dehydrogenase1.8.1.41.000
4jq9FADDihydrolipoyl dehydrogenase/0.521
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.519
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.514
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.514
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.497
2eq9FADDihydrolipoyl dehydrogenase/0.496
2r9zFADGlutathione amide reductase/0.492
1zk7FADMercuric reductase1.16.1.10.491
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.491
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.491
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.486
2eq8FADDihydrolipoyl dehydrogenase/0.484
3ladFADDihydrolipoyl dehydrogenase/0.483
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.483
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.482
2eq6FADDihydrolipoyl dehydrogenase/0.482
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.481
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.481
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.481
3grsFADGlutathione reductase, mitochondrial1.8.1.70.481
4j56FADThioredoxin reductase 21.8.1.90.479
4eqwFADCoenzyme A disulfide reductase/0.475
1greFADGlutathione reductase, mitochondrial1.8.1.70.474
1grhFADGlutathione reductase, mitochondrial1.8.1.70.474
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.473
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.471
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.469
1grgFADGlutathione reductase, mitochondrial1.8.1.70.468
1nhpFADNADH peroxidase1.11.1.10.468
1zx9FADMercuric reductase1.16.1.10.468
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.468
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.467
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.466
2v6oFADThioredoxin glutathione reductase/0.466
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.466
3urhFADDihydrolipoyl dehydrogenase/0.466
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.465
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.464
1graFADGlutathione reductase, mitochondrial1.8.1.70.462
1nhqFADNADH peroxidase1.11.1.10.462
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.457
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.457
4dnaFADProbable glutathione reductase/0.455
1geuFADGlutathione reductase1.8.1.70.452
1yqzFADCoenzyme A disulfide reductase/0.449
1feaFADTrypanothione reductase1.8.1.120.448
3cgcFADCoenzyme A disulfide reductase/0.448
3ctyFADProbable thioredoxin reductase/0.448
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.447
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.446
1febFADTrypanothione reductase1.8.1.120.445
1nhrFADNADH peroxidase1.11.1.10.445
1f8wFADNADH peroxidase1.11.1.10.443
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.442
3cgbFADCoenzyme A disulfide reductase/0.441
4eqsFADCoenzyme A disulfide reductase/0.440