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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1dirNADDihydropteridine reductase1.5.1.34

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1dirNADDihydropteridine reductase1.5.1.341.000
1dhrNADDihydropteridine reductase1.5.1.340.615
1hdrNADDihydropteridine reductase1.5.1.340.563
3orfNADDihydropteridine reductase1.5.1.340.529
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.498
1bwsNDPGDP-L-fucose synthase/0.494
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.486
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.483
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.483
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.483
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.481
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.476
3ig6438Urokinase-type plasminogen activator3.4.21.730.475
4q71FADBifunctional protein PutA/0.471
2bpw1INGag-Pol polyprotein3.4.23.160.467
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.466
4xguADPPutative pachytene checkpoint protein 2/0.466
3f1kNAPUncharacterized oxidoreductase YciK10.464
1kkq471Peroxisome proliferator-activated receptor alpha/0.463
2rcyNAPPyrroline-5-carboxylate reductase/0.463
3q43D66M1 family aminopeptidase3.4.110.463
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.462
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
1udaUFGUDP-glucose 4-epimerase5.1.3.20.460
3b6zCO7Enoyl reductase LovC10.460
3t3c017Gag-Pol polyprotein3.4.23.160.460
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.458
1g6kNADGlucose 1-dehydrogenase1.1.1.470.457
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1udbUFGUDP-glucose 4-epimerase5.1.3.20.457
5c41ACPRibokinase/0.457
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.456
2wf4ZY4Beta-secretase 13.4.23.460.456
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.456
1qrpHH0Pepsin A-43.4.23.10.455
2c20NADUDP-glucose 4-epimerase/0.455
2ejzSAHDiphthine synthase/0.455
1gqtACPRibokinase/0.454
1ha3MAUElongation factor Tu-A/0.454
1bxqPP8Penicillopepsin-13.4.23.200.453
1lf3EH5Plasmepsin-23.4.23.390.453
1w6hTITPlasmepsin-23.4.23.390.452
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.452
3gw9VNILanosterol 14-alpha-demethylase/0.452
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.452
1c6yMK1Protease/0.451
1fxsNAPGDP-L-fucose synthase/0.451
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.451
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.451
2dteNAIGlucose 1-dehydrogenase related protein/0.450
3lpjZ75Beta-secretase 13.4.23.460.450
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
3b70NAPEnoyl reductase LovC10.449
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.449
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.449
1msmJE2Gag-Pol polyprotein3.4.23.160.448
1xe55FEPlasmepsin-23.4.23.390.448
4nbwNADShort-chain dehydrogenase/reductase SDR/0.448
1xddAAYIntegrin alpha-L/0.447
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.447
3bgbLJGGag-Pol polyprotein3.4.23.160.446
3mk6ACOPantothenate kinase 32.7.1.330.446
3q44D50M1 family aminopeptidase3.4.110.446
4o1mNADEnoyl-acyl carrier reductase/0.446
1bxoPP7Penicillopepsin-13.4.23.200.445
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1k6tXN1Gag-Pol polyprotein3.4.23.160.445
1ma0NADAlcohol dehydrogenase class-31.1.1.10.445
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
2x9dITCTetracycline repressor protein class D/0.445
3zpuM8BGag-Pol polyprotein3.4.23.160.445
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
2e07SAHDiphthine synthase/0.444
2g1s4IGRenin3.4.23.150.444
3nxe2NCProtease/0.444
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.444
4dc0NDPPutative ketoacyl reductase1.3.10.444
3nwxKVSGag-Pol polyprotein3.4.23.160.443
4e5yNDPGDP-L-fucose synthase1.1.1.2710.443
4g3jVNTLanosterol 14-alpha-demethylase/0.443
5dp2NAPCurF/0.443
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
3slkNDPPolyketide synthase extender module 2/0.442
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2ejvNADL-threonine 3-dehydrogenase/0.441
4a6cQG9Gag-Pol polyprotein3.4.23.160.441
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.441
1yb5NAPQuinone oxidoreductase1.6.5.50.440
3r9uFADThioredoxin reductase/0.440
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.440
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440