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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1db48INPhospholipase A2, membrane associated

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1db48INPhospholipase A2, membrane associated/1.000
1dcyI3NPhospholipase A2, membrane associated/0.733
1db56INPhospholipase A2, membrane associated/0.655
1kquBR4Phospholipase A2, membrane associated/0.613
3u8hBHPPhospholipase A2, membrane associated/0.571
3u8dU8DPhospholipase A2, membrane associated/0.552
1kvoOAPPhospholipase A2, membrane associated/0.540
1aypINBPhospholipase A2, membrane associated/0.527
5p2pDHGPhospholipase A2, major isoenzyme3.1.1.40.519
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.493
3njuANNAcidic phospholipase A2 33.1.1.40.475
2iko7IGRenin3.4.23.150.473
2x9dITCTetracycline repressor protein class D/0.471
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.469
4qerSTLPhospholipase A2 VRV-PL-VIIIa/0.468
3tdaPN0Cytochrome P450 2D6/0.465
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.459
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.456
1fmlRTLRetinol dehydratase/0.455
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
4hmbPZZPhospholipase A2 VRV-PL-VIIIa/0.455
4a83DXCMajor pollen allergen Bet v 1-A/0.454
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.453
4qmySTUSerine/threonine-protein kinase 242.7.11.10.452
2oliIOPBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.451
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.451
1vbmYSATyrosine--tRNA ligase6.1.1.10.450
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.450
2am22LGUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.448
3oibFDAPutative acyl-CoA dehydrogenase/0.448
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.448
3f63GTXGlutathione transferase GST1-4/0.447
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.447
3oqkS52Renin3.4.23.150.446
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.445
1p8dCO1Oxysterols receptor LXR-beta/0.444
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.443
2xlsFADPutative flavin-containing monooxygenase/0.443
3frkTQPQdtB/0.442
4a802ANMajor pollen allergen Bet v 1-A/0.442
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.441
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441