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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5env NAD Alcohol dehydrogenase 1 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5env NADAlcohol dehydrogenase 1 1.1.1.1 1.180
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.928
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.918
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.861
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.856
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.836
3two NDPMannitol dehydrogenase / 0.835
3jv7 NADSecondary alcohol dehydrogenase / 0.829
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.826
4oaq NDPR-specific carbonyl reductase / 0.826
4c4o NADSADH / 0.821
2xaa NADSecondary alcohol dehydrogenase / 0.816
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.803
3wle NAD(R)-specific carbonyl reductase / 0.795
1yqd NAPSinapyl alcohol dehydrogenase / 0.790
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.787
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.786
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.786
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.784
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.784
1llu NADAlcohol dehydrogenase / 0.776
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.775
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.775
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.774
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.774
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.774
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.773
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.773
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.766
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.765
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.764
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.763
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.760
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.759
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.759
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.758
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.755
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.754
1yqx NAPSinapyl alcohol dehydrogenase / 0.752
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.751
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.748
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.746
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.740
1uxj NADMalate dehydrogenase / 0.736
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.736
4i1i NADMalate dehydrogenase / 0.735
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.731
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.726
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.723
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.720
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.719
4j43 NADUncharacterized protein / 0.719
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.718
1x7d NADPutative ornithine cyclodeaminase / 0.715
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.713
4jk3 NADUncharacterized protein / 0.713
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.712
1pzh NADLactate dehydrogenase / 0.710
4b7x NAPProbable oxidoreductase / 0.708
1uxk NADMalate dehydrogenase / 0.705
4k28 NADShikimate dehydrogenase family protein / 0.705
1sow NADL-lactate dehydrogenase 1.1.1.27 0.702
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.698
2y05 NAPProstaglandin reductase 1 / 0.698
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.697
1o6z NADMalate dehydrogenase / 0.697
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.696
1u7h NADPutative ornithine cyclodeaminase / 0.695
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.693
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.692
4j49 NADUncharacterized protein / 0.691
4j4b NAIUncharacterized protein / 0.691
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.690
1pzf A3DLactate dehydrogenase / 0.690
1wze NADMalate dehydrogenase / 0.690
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.687
1ib6 NADMalate dehydrogenase / 0.686
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.685
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.684
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.684
2x0i NAIMalate dehydrogenase / 0.683
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.682
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.682
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.679
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.679
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.677
3x2f NAIAdenosylhomocysteinase / 0.676
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.675
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.675
3wyc NAPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.673
4plp NADHomospermidine synthase 2.5.1.44 0.673
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.672
2x0r NADMalate dehydrogenase / 0.672
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.671
4xqc NADHomospermidine synthase 2.5.1.44 0.670
1gv0 NADMalate dehydrogenase / 0.669
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.668
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.668
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.668
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.667
1wzi NDPMalate dehydrogenase / 0.667
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.667
2a92 NAIL-lactate dehydrogenase / 0.665
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.664
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.664
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.663
3m2t NADProbable dehydrogenase / 0.663
3oet NADErythronate-4-phosphate dehydrogenase / 0.663
4xyb NDPFormate dehydrogenase / 0.663
3tqh NDPQuinone oxidoreductase / 0.662
1pjc NADAlanine dehydrogenase / 0.661
3d64 NADAdenosylhomocysteinase / 0.661
3nx4 NAPPutative oxidoreductase / 0.661
4tvb NADHomospermidine synthase 2.5.1.44 0.661
2dbz NAPGlyoxylate reductase 1.1.1.26 0.660
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.660
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.660
4rqu NADAlcohol dehydrogenase class-P / 0.660
1b8u NADMalate dehydrogenase / 0.657
3t4e NADQuinate/shikimate dehydrogenase / 0.656
1ie3 NADMalate dehydrogenase / 0.655
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.654
2b5v NAPGlucose 1-dehydrogenase / 0.653
1xq6 NAPUncharacterized protein At5g02240 / 0.652
2dph NADFormaldehyde dismutase / 0.652
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.652
3adp NAILambda-crystallin 1.1.1.45 0.652
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.652
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.651
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.651
5dp2 NAPCurF / 0.651
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.650
4xrg NADHomospermidine synthase 2.5.1.44 0.650