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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5c7h NDP Putative oxidoreductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5c7h NDPPutative oxidoreductase / 1.410
4pmj NAPPutative oxidoreductase / 1.337
2pf8 NDPAldose reductase 1.1.1.21 1.237
2pev NDPAldose reductase 1.1.1.21 1.236
1x98 NAPAldose reductase 1.1.1.21 1.223
2j8t NAPAldose reductase 1.1.1.21 1.216
1z8a NAPAldose reductase 1.1.1.21 1.215
3uzw NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.214
3h7u NAPNADPH-dependent aldo-keto reductase, chloroplastic / 1.209
3q67 NAPAldose reductase 1.1.1.21 1.205
1vp5 NAPOxidoreductase, aldo/keto reductase family / 1.202
3bv7 NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.198
2iq0 NAPAldose reductase 1.1.1.21 1.194
1ads NAPAldose reductase 1.1.1.21 1.190
1x96 NAPAldose reductase 1.1.1.21 1.190
3g1r NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.185
2acq NAPAldose reductase 1.1.1.21 1.177
2bgs NDPAldose reductase 1.1.1.21 1.170
2acs NAPAldose reductase 1.1.1.21 1.166
3v36 NAPAldose reductase 1.1.1.21 1.159
3buv NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.155
3dop NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.147
2acu NAPAldose reductase 1.1.1.21 1.127
1ah4 NAPAldose reductase 1.1.1.21 1.094
3h7r NAPAldo-keto reductase family 4 member C8 / 1.092
2pfh NDPAldose reductase 1.1.1.21 1.086
1ef3 NAPAldose reductase 1.1.1.21 1.071
3caq NDP3-oxo-5-beta-steroid 4-dehydrogenase / 1.068
1a80 NDP2,5-diketo-D-gluconic acid reductase A 1.1.1.346 1.058
3q65 NAPAldose reductase 1.1.1.21 1.058
2vdg NDPAldose reductase 1.1.1.21 1.052
3o3r NAPAldose reductase-related protein 1 1.1.1.21 1.037
4g5d NDPProstaglandin F synthase 1.1.1.188 1.027
1q5m NDPProstaglandin-E(2) 9-reductase 1.1.1.189 1.014
4xzn NAPAldo-keto reductase family 1 member B10 1.1.1 1.006
4ijr NDPD-arabinose dehydrogenase [NAD(P)+] heavy chain 1.1.1.117 0.996
3qkz NAPAldose reductase-related protein 1 1.1.1.21 0.994
4jtq NAPAldo-keto reductase family 1 member C2 / 0.987
4xo7 NAPAldo-keto reductase family 1 member C2 / 0.984
4l1x NAPAldo-keto reductase family 1 member C2 / 0.981
1hqt NAPAlcohol dehydrogenase [NADP(+)] 1.1.1.2 0.980
1k8c NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.954
3wbw NDPPutative 2,5-diketo-D-gluconic acid reductase / 0.944
4xzm NAPAldo-keto reductase family 1 member B10 1.1.1 0.925
1az2 NAPAldose reductase 1.1.1.21 0.916
1s1r NAPAldo-keto reductase family 1 member C3 / 0.912
2hdj NDPAldo-keto reductase family 1 member C2 / 0.912
3wcz NAPAldo-keto reductase AKR2E4 / 0.902
4jq3 NAPAldo-keto reductase family 1 member C2 / 0.899
2fvl NAPAldo-keto reductase family 1 member C4 1.1.1.225 0.891
1s1p NAPAldo-keto reductase family 1 member C3 / 0.887
1zgd NAPChalcone reductase / 0.884
4dz5 NAPAldo-keto reductase family 1 member C3 / 0.877
1c9w NAPAldose reductase-related protein 2 / 0.849
1m9h NAD2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.841
1r38 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.841
1sm9 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.815
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.780
1ye4 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.767
1ye6 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.762
2he5 NDPAldo-keto reductase family 1 member C21 1.1.1 0.757
3wg6 NDPNADPH-dependent conjugated polyketone reductase C1 / 0.746
2bp1 NDPAflatoxin B1 aldehyde reductase member 2 / 0.745
1z9a NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.731
1mi3 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.724
4aub NAPL-glyceraldehyde 3-phosphate reductase 1.1.1 0.715
3ln3 NADAldo-keto reductase family 1 member C13 / 0.714
2clp NDPAflatoxin B1 aldehyde reductase member 3 / 0.700
4h8n NDPNADPH-dependent conjugated polyketone reductase C2 / 0.683
2p5n NDPAldo-keto reductase family 1 member C21 1.1.1 0.680
2hej NDPAldo-keto reductase family 1 member C21 1.1.1 0.671
1og6 NAPOxidoreductase YdhF 1 0.667