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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ywj NAD 4-hydroxy-tetrahydrodipicolinate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 1.096
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.814
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.777
1gv0 NADMalate dehydrogenase / 0.756
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.745
1o6z NADMalate dehydrogenase / 0.739
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.738
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.735
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.735
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.729
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.725
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
4b7x NAPProbable oxidoreductase / 0.718
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.717
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.715
1xcb NADRedox-sensing transcriptional repressor Rex / 0.713
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.713
2y05 NAPProstaglandin reductase 1 / 0.712
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.712
1yqd NAPSinapyl alcohol dehydrogenase / 0.711
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.706
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.704
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.702
2x0i NAIMalate dehydrogenase / 0.701
4k28 NADShikimate dehydrogenase family protein / 0.701
1do8 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.698
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.698
1uxk NADMalate dehydrogenase / 0.696
1llu NADAlcohol dehydrogenase / 0.695
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.695
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.695
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.694
3two NDPMannitol dehydrogenase / 0.694
2o4c NADErythronate-4-phosphate dehydrogenase / 0.693
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.692
1emd NADMalate dehydrogenase / 0.690
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.690
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.689
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.689
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.688
1uxj NADMalate dehydrogenase / 0.688
4c4o NADSADH / 0.688
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.687
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.685
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.685
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.683
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.683
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.681
1c1d NAIPhenylalanine dehydrogenase / 0.680
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.679
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.679
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.678
1pzh NADLactate dehydrogenase / 0.676
5lc1 NADL-threonine 3-dehydrogenase / 0.676
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.675
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.675
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.675
4cpd NADAlcohol dehydrogenase / 0.675
3keo NADRedox-sensing transcriptional repressor Rex / 0.674
4j4b NAIUncharacterized protein / 0.674
4jk3 NADUncharacterized protein / 0.674
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.673
2hjr APRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase / 0.673
3qwb NDPProbable quinone oxidoreductase 1.6.5.5 0.673
3wle NAD(R)-specific carbonyl reductase / 0.673
1yqx NAPSinapyl alcohol dehydrogenase / 0.671
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.671
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.671
1wze NADMalate dehydrogenase / 0.670
3abi NADUncharacterized protein / 0.670
2pv7 NADT-protein 1.3.1.12 0.667
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.665
3f3s NADLambda-crystallin homolog / 0.665
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.664
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.663
3k2b NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.663
3x2f NAIAdenosylhomocysteinase / 0.663
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.663
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.662
3q2k NAIProbable oxidoreductase / 0.662
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.661
3l4s NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.661
4i1i NADMalate dehydrogenase / 0.661
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.660
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.660
3d64 NADAdenosylhomocysteinase / 0.660
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.659
2ome NADC-terminal-binding protein 2 / 0.658
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.658
1ur5 NADMalate dehydrogenase / 0.657
3hja NADGlyceraldehyde-3-phosphate dehydrogenase / 0.657
1gae NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.656
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.656
2vyn NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.656
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
1nqa NADGlyceraldehyde-3-phosphate dehydrogenase / 0.655
2gsd NADFormate dehydrogenase / 0.655
1f8f NADBenzyl alcohol dehydrogenase / 0.654
1nqo NADGlyceraldehyde-3-phosphate dehydrogenase / 0.654
1szj NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.654
1gyp NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.653
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.653
3jv7 NADSecondary alcohol dehydrogenase / 0.652
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.651
4xq9 NADHomospermidine synthase 2.5.1.44 0.651
3doc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.650
4idg NADPutative UDP-glucose 4-epimerase / 0.650