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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4oqy NDP (S)-imine reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4oqy NDP(S)-imine reductase / 1.290
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.899
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.898
2hk9 NAPShikimate dehydrogenase (NADP(+)) / 0.843
3zhb NAPPutative dehydrogenase / 0.834
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.822
2iyp NAP6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.761
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.757
1nyt NAPShikimate dehydrogenase (NADP(+)) / 0.754
3h2s NDPPutative NADH-flavin reductase / 0.749
4xb1 NDP319aa long hypothetical homoserine dehydrogenase / 0.735
3dtt NAPNADP oxidoreductase, coenzyme F420-dependent / 0.734
3ing NDPHomoserine dehydrogenase related protein / 0.730
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.727
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.723
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.723
1vi2 NADQuinate/shikimate dehydrogenase / 0.722
2hk9 ATRShikimate dehydrogenase (NADP(+)) / 0.719
3t4e NADQuinate/shikimate dehydrogenase / 0.717
1npd NADQuinate/shikimate dehydrogenase / 0.712
4xb2 NDP319aa long hypothetical homoserine dehydrogenase / 0.701
2cdc NAPGlucose 1-dehydrogenase / 0.698
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.695
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.694
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.692
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.690
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.688
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.688
2yut NAPPutative short-chain oxidoreductase / 0.688
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.688
1i36 NAPConserved protein / 0.686
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.686
1o9b NAIQuinate/shikimate dehydrogenase / 0.685
2iyp A2P6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.685
3a14 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.685
3e8x NAPBH1520 protein / 0.681
1pr9 NAPL-xylulose reductase 1.1.1.10 0.678
3q3c NADNAD-dependent L-serine dehydrogenase / 0.678
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.676
4ovi N01Phenylacetone monooxygenase 1.14.13.92 0.675
4xgi NADGlutamate dehydrogenase / 0.673
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.671
4tqg NDPPutative dTDP-d-glucose 4 6-dehydratase / 0.670
2uyy NA7Putative oxidoreductase GLYR1 1 0.668
1n7h NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.667
1cf2 NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.665
4u7w NDPMxaA / 0.665
3ggp NADPrephenate dehydrogenase / 0.664
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.662
4l8g GDPGTPase KRas / 0.661
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.660
2cda NAPGlucose 1-dehydrogenase / 0.660
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.660
4a5l NDPThioredoxin reductase / 0.660
4kwh NAPReductase homolog / 0.660
4d04 NAPPhenylacetone monooxygenase 1.14.13.92 0.659
5a9s NAPPutative dehydrogenase / 0.659
2q0l NAPThioredoxin reductase 1.8.1.9 0.657
4d03 NAPPhenylacetone monooxygenase 1.14.13.92 0.656
2c0c NAPProstaglandin reductase 3 1 0.655
2e9o A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.655
3mvq NDPGlutamate dehydrogenase 1, mitochondrial 1.4.1.3 0.655
4j7u NAPSepiapterin reductase 1.1.1.153 0.655
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.654
2ph5 NADHomospermidine synthase / 0.654
1oaa NAPSepiapterin reductase 1.1.1.153 0.653
4gcm NAPThioredoxin reductase 1.8.1.9 0.653
3abi NADUncharacterized protein / 0.652
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.651
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.651
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.651
2voj NADAlanine dehydrogenase 1.4.1.1 0.650