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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4o0u ADN Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4o0u ADNAurora kinase A 2.7.11.1 0.747
4ceg ADPAurora kinase A 2.7.11.1 0.716
1mq4 ADPAurora kinase A 2.7.11.1 0.715
2dwb ANPAurora kinase A 2.7.11.1 0.708
5dn3 ATPAurora kinase A 2.7.11.1 0.707
5dt3 ATPAurora kinase A 2.7.11.1 0.706
4bn1 ADPAurora kinase A 2.7.11.1 0.704
4utd ACPAurora kinase A 2.7.11.1 0.694
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.692
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.691
5dr2 ATPAurora kinase A 2.7.11.1 0.689
5dt4 ATPAurora kinase A 2.7.11.1 0.688
4o0w ADNAurora kinase A 2.7.11.1 0.687
4dee ADPAurora kinase A 2.7.11.1 0.686
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.684
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.679
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.679
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.677
5ce3 ADPProtein kinase YopO / 0.676
5dnr ATPAurora kinase A 2.7.11.1 0.675
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.672
5drd ATPAurora kinase A 2.7.11.1 0.672
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.671
4o0s ADNAurora kinase A 2.7.11.1 0.671
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.670
3nie ANPMitogen-activated protein kinase / 0.670
5dos ATPAurora kinase A 2.7.11.1 0.670
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.669
3ork AGSSerine/threonine protein kinase / 0.668
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.668
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.667
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.666
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.666
4qny ANPMitogen activated protein kinase, putative / 0.665
4ysj ADPCalmodulin-like domain protein kinase / 0.664
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.663
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.663
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.662
4c3r ACPAurora kinase A 2.7.11.1 0.661
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.661
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.661
1ol5 ADPAurora kinase A 2.7.11.1 0.660
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.659
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.659
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.659
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.658
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.658
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.656
1ol6 ATPAurora kinase A 2.7.11.1 0.655
3c4w ATPRhodopsin kinase / 0.655
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.655
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.654
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.654
4hut ATPCob(I)yrinic acid a,c-diamide adenosyltransferase 2.5.1.17 0.653
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.652
3cly ACPFibroblast growth factor receptor 2 / 0.652
3t8o ATPRhodopsin kinase / 0.652
3u4l ATPActin, cytoplasmic 1 / 0.652
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.651
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.651
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.650