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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mgi CMP Rap guanine nucleotide exchange factor 4

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mgi CMPRap guanine nucleotide exchange factor 4 / 0.932
4mgk CMPRap guanine nucleotide exchange factor 4 / 0.720
1rgs CMPcAMP-dependent protein kinase type I-alpha regulatory subunit / 0.714
4qx5 CMPcGMP-dependent protein kinase 1 2.7.11.12 0.708
3i59 N6SCRP-like cAMP-activated global transcriptional regulator / 0.705
3u10 CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.704
4ku7 PCGcGMP-dependent protein kinase 1 2.7.11.12 0.704
1cx4 CMPcAMP-dependent protein kinase type II-beta regulatory subunit / 0.703
1q43 CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.693
3r6s CMPCRP-like cAMP-activated global transcriptional regulator / 0.693
4hbn CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 / 0.690
1g6n CMPcAMP-activated global transcriptional regulator CRP / 0.688
4ev0 CMPCyclic AMP receptor protein / 0.680
2ptm CMPHyperpolarization-activated (Ih) channel / 0.679
4n9i PCGCatabolite expression activator / 0.679
1hw5 CMPcAMP-activated global transcriptional regulator CRP / 0.677
1q5o CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.677
3otf CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 / 0.673
4jv4 1ORcAMP-dependent protein kinase type I-alpha regulatory subunit / 0.671
3u0z CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 / 0.669
4z07 PCGcGMP-dependent protein kinase 1 2.7.11.12 0.669
1q3e PCGPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.667
3cl1 PCGCyclic nucleotide-gated potassium channel mll3241 / 0.665
3ocp CMPcGMP-dependent protein kinase 1 2.7.11.12 0.662
1ne4 RP1cAMP-dependent protein kinase type I-alpha regulatory subunit / 0.658
4ft8 CMPcAMP-activated global transcriptional regulator CRP / 0.655
4d7t CMPUncharacterized protein / 0.654
1vp6 CMPCyclic nucleotide-gated potassium channel mll3241 / 0.653
2ouy CMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17 0.653
3bbf GDPNucleoside diphosphate kinase B 2.7.4.6 0.653
4i02 CMPcAMP-activated global transcriptional regulator CRP / 0.652
1n07 ADPRiboflavin kinase 2.7.1.26 0.650
3n4m CMPcAMP-activated global transcriptional regulator CRP / 0.650