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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ejm NAP Putative zinc-binding dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ejm NAPPutative zinc-binding dehydrogenase / 1.227
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.778
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.778
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.778
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.778
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.765
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.764
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.762
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.759
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.759
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.754
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.749
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.748
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.746
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.745
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.744
4y1b NAPAntE / 0.744
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.744
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.742
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.742
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.730
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.730
4cpd NADAlcohol dehydrogenase / 0.730
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.729
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.728
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.726
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.726
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.722
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.721
4gl4 NAIAlcohol dehydrogenase class-3 / 0.719
1d4o NAPNAD(P) transhydrogenase, mitochondrial / 0.716
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.716
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.714
4xyb NDPFormate dehydrogenase / 0.711
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.709
3wle NAD(R)-specific carbonyl reductase / 0.706
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.705
4bms NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.703
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.698
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.698
4l0q NADAlcohol dehydrogenase class-3 / 0.698
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.697
1oaa NAPSepiapterin reductase 1.1.1.153 0.696
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.696
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.695
4y0k NAPAntE / 0.694
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.693
1yqd NAPSinapyl alcohol dehydrogenase / 0.692
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.691
3jv7 NADSecondary alcohol dehydrogenase / 0.689
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.688
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.688
4l4x NDPAmphI / 0.688
3jyn NDPQuinone oxidoreductase / 0.686
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.686
3mje NDPAmphB / 0.686
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.684
1f8f NADBenzyl alcohol dehydrogenase / 0.682
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.681
2jah NDPClavaldehyde dehydrogenase / 0.680
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.680
4jji NADAlcohol dehydrogenase class-3 / 0.679
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.678
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.675
2tsr UMPThymidylate synthase 2.1.1.45 0.670
1uxj NADMalate dehydrogenase / 0.669
5doz NDPJamJ / 0.669
2xaa NADSecondary alcohol dehydrogenase / 0.667
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.666
3tn7 NJPShort-chain alcohol dehydrogenase / 0.666
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.666
4tqg NDPPutative dTDP-d-glucose 4 6-dehydratase / 0.665
2vwh NAPGlucose 1-dehydrogenase / 0.664
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.664
2dbz NAPGlyoxylate reductase 1.1.1.26 0.663
3two NDPMannitol dehydrogenase / 0.662
1bdm NAXMalate dehydrogenase / 0.661
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.661
3l77 NJPShort-chain alcohol dehydrogenase / 0.661
3p74 FMNPentaerythritol tetranitrate reductase / 0.661
1udb UFGUDP-glucose 4-epimerase 5.1.3.2 0.658
4hxy NDPPlm1 / 0.658
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.657
2x0r NADMalate dehydrogenase / 0.657
1qor NDPQuinone oxidoreductase 1 / 0.656
1u28 NAPNAD(P) transhydrogenase subunit beta 1.6.1.2 0.656
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.655
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.655
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.654
2jkv NAP6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.654
4j16 NAPNAD(P) transhydrogenase subunit beta / 0.654
1fnd A2PFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.653
1pzh NADLactate dehydrogenase / 0.653
1jn0 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.652
1pjc NADAlanine dehydrogenase / 0.652
2d8a NADL-threonine 3-dehydrogenase / 0.651
3qwb NDPProbable quinone oxidoreductase 1.6.5.5 0.651
3tri NAPPyrroline-5-carboxylate reductase / 0.651
4df2 FMNNADPH dehydrogenase / 0.651
2b5v NAPGlucose 1-dehydrogenase / 0.650
2c3c NAP2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.650
2zat NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.650
3abi NADUncharacterized protein / 0.650
4gcm NAPThioredoxin reductase 1.8.1.9 0.650
4to4 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.650