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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bcq TJF Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bcq TJFCyclin-dependent kinase 2 2.7.11.22 0.865
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3nux 3NVCyclin-dependent kinase 6 2.7.11.22 0.691
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.690
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.681
4brx KGWFocal adhesion kinase 1 2.7.10.2 0.679
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.678
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.675
3rzb 02ZCyclin-dependent kinase 2 2.7.11.22 0.669
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.668
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.667
2vww 7X2Ephrin type-B receptor 4 2.7.10.1 0.665
4bcn T9NCyclin-dependent kinase 2 2.7.11.22 0.662
4bcp T3CCyclin-dependent kinase 2 2.7.11.22 0.662
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.660
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.659
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.659
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.657
3rkb 12ZCyclin-dependent kinase 2 2.7.11.22 0.656
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.655
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.654
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.651
3unj 0BXCyclin-dependent kinase 2 2.7.11.22 0.651
4izy 1J2Mitogen-activated protein kinase 8 2.7.11.24 0.651
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.650