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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bbe 3O4 Tyrosine-protein kinase JAK2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.973
4bbf O19Tyrosine-protein kinase JAK2 / 0.767
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.744
2x81 ZZLAurora kinase A 2.7.11.1 0.733
2pvl P55Casein kinase II subunit alpha 2.7.11.1 0.694
4grb 0XGCasein kinase II subunit alpha 2.7.11.1 0.694
4b0g VEKAurora kinase A 2.7.11.1 0.681
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.681
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.680
4bcq TJFCyclin-dependent kinase 2 2.7.11.22 0.678
4aqc 88ATyrosine-protein kinase JAK2 / 0.674
4ftt 6HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.673
3bea IXHMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.671
5dr9 SKEAurora kinase A 2.7.11.1 0.671
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.666
4jia 1K3Tyrosine-protein kinase JAK2 / 0.663
4e5f 0N7Polymerase acidic protein / 0.660
1y57 MPZProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.658
3lpb NVBTyrosine-protein kinase JAK2 / 0.657
3ocs 746Tyrosine-protein kinase BTK 2.7.10.2 0.656
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.653
1z5m LI83-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
4j53 1J4Serine/threonine-protein kinase PLK1 2.7.11.21 0.651
4dea NHIAurora kinase A 2.7.11.1 0.650