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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ap1 FAD Steroid monooxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ap1 FADSteroid monooxygenase / 1.109
4aos FADSteroid monooxygenase / 1.041
4ap3 FADSteroid monooxygenase / 1.002
4aox FADSteroid monooxygenase / 0.923
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.798
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.788
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.785
3gwf FADCyclohexanone monooxygenase / 0.782
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.772
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.753
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.750
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.746
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.744
2gv8 FADThiol-specific monooxygenase 1.14.13 0.736
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.735
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.734
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.732
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.730
2yqu FADDihydrolipoyl dehydrogenase / 0.730
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.719
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.718
4cnk FADL-amino acid oxidase / 0.716
3urh FADDihydrolipoyl dehydrogenase / 0.708
2xvf FADPutative flavin-containing monooxygenase / 0.706
4tlz FADKtzI / 0.705
3lsh FADPyranose 2-oxidase / 0.703
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.703
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.701
1get FADGlutathione reductase 1.8.1.7 0.700
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.700
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.700
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.698
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.697
2gvc FADThiol-specific monooxygenase 1.14.13 0.697
3pl8 FADPyranose 2-oxidase / 0.696
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.695
4b66 FADL-ornithine N(5)-monooxygenase / 0.693
4gus FADLysine-specific histone demethylase 1B 1 0.692
4jq9 FADDihydrolipoyl dehydrogenase / 0.692
2eq7 FADDihydrolipoyl dehydrogenase / 0.688
4tm4 FDAKtzI / 0.688
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.686
3rha FDAPutrescine oxidase / 0.685
4j57 FADThioredoxin reductase 2 1.8.1.9 0.685
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.684
3gwd FADCyclohexanone monooxygenase / 0.683
2zbw FADFerredoxin--NADP reductase / 0.681
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.681
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.681
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.680
4usr FADMonooxygenase / 0.678
4mok FADPyranose 2-oxidase / 0.676
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.675
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.675
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.675
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.674
3mj4 FADUDP-galactopyranose mutase / 0.674
1y56 ATPUncharacterized protein / 0.673
3bg7 FADPyranose 2-oxidase / 0.673
3lsi FADPyranose 2-oxidase / 0.673
4b65 FADL-ornithine N(5)-monooxygenase / 0.673
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.672
2eq6 FADDihydrolipoyl dehydrogenase / 0.672
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.672
3cnd FADPolyamine oxidase FMS1 / 0.671
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.670
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.670
2igo FADPyranose 2-oxidase / 0.670
4z24 FADPutative GMC-type oxidoreductase R135 1 0.670
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.669
3atr FDAConserved Archaeal protein / 0.669
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.668
4c5o FADPutative monooxygenase / 0.668
2iw5 FADLysine-specific histone demethylase 1A 1 0.667
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.666
2ign FADPyranose 2-oxidase / 0.665
2yg3 FADPutrescine oxidase / 0.665
3gyj FADCholesterol oxidase 1.1.3.6 0.665
3k4c FADPyranose 2-oxidase / 0.664
4la1 FADThioredoxin glutathione reductase / 0.664
3k30 ADPHistamine dehydrogenase / 0.661
4gut FADLysine-specific histone demethylase 1B 1 0.661
4tm3 FADKtzI / 0.661
1ojt FADDihydrolipoyl dehydrogenase / 0.660
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.660
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.659
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.658
2x8g FADThioredoxin glutathione reductase / 0.658
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.657
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.657
2npx FADNADH peroxidase 1.11.1.1 0.657
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.657
2eq8 FADDihydrolipoyl dehydrogenase / 0.656
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.656
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.655
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.655
1geu FADGlutathione reductase 1.8.1.7 0.655
4guu FA9Lysine-specific histone demethylase 1B 1 0.655
2x8h FADThioredoxin glutathione reductase / 0.654
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.654
3f8p NADNADH oxidase/thioredoxin reductase / 0.654
4b69 FADL-ornithine N(5)-monooxygenase / 0.654
4b68 FADL-ornithine N(5)-monooxygenase / 0.653
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.652
2yg7 FADPutrescine oxidase / 0.652
3ict FADCoenzyme A disulfide reductase / 0.651
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.651
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.650
4tlx FDAKtzI / 0.650