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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3to6 LYS_CMC Histone acetyltransferase ESA1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3to6 LYS_CMCHistone acetyltransferase ESA1 / 1.326
1fy7 COAHistone acetyltransferase ESA1 / 1.093
1mja COAHistone acetyltransferase ESA1 / 1.091
1mjb ACOHistone acetyltransferase ESA1 / 1.043
2ou2 ACOHistone acetyltransferase KAT5 / 1.002
1mj9 COAHistone acetyltransferase ESA1 / 0.987
2ozu ACOHistone acetyltransferase KAT6A / 0.980
2y0m ACOHistone acetyltransferase KAT8 / 0.895
2giv ACOHistone acetyltransferase KAT8 / 0.894
2rc4 ACOHistone acetyltransferase KAT6A / 0.843
2fiw ACOGCN5-related N-acetyltransferase:Aminotransferase, class-II / 0.836
1qsr ACOHAT A1 / 0.821
3exn ACOProbable acetyltransferase / 0.812
4r3k COAN-alpha-acetyltransferase 2.3.1 0.803
5kf1 ACOPredicted acetyltransferase / 0.799
1wwz ACOUncharacterized protein / 0.798
2cns ACORibosomal-protein-alanine acetyltransferase / 0.798
4lx9 ACON-alpha-acetyltransferase 2.3.1 0.798
4hkf ACOAlpha-tubulin N-acetyltransferase 1 / 0.791
2r8v ACOAmino-acid acetyltransferase / 0.787
4mxe ACON-acetyltransferase ESCO1 2.3.1 0.786
1bo4 COAAminoglycoside-(3)-N-acetyltransferase / 0.784
5kgh ACOPredicted acetyltransferase / 0.781
4ag7 COAGlucosamine 6-phosphate N-acetyltransferase / 0.779
2jdc CAOProbable acetyltransferase / 0.778
2jdd ACOProbable acetyltransferase / 0.775
4kvx ACON-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.768
1m1d LYXHAT A1 / 0.763
3fbu COAAcetyltransferase, GNAT family / 0.763
1ozp ACOMycothiol acetyltransferase 2.3.1.189 0.762
4b5p ACOAlpha-tubulin N-acetyltransferase 1 / 0.762
5kf8 ACOPredicted acetyltransferase / 0.762
2cnt COARibosomal-protein-alanine acetyltransferase / 0.761
3d2m COAAmino-acid acetyltransferase / 0.761
5kf9 ACOPredicted acetyltransferase / 0.761
1p0h COAMycothiol acetyltransferase 2.3.1.189 0.758
2bsw CAOProbable acetyltransferase / 0.758
1cm0 COAHistone acetyltransferase KAT2B 2.3.1.48 0.755
5kgp ACOPredicted acetyltransferase / 0.755
3vwd ACOAlpha-tubulin N-acetyltransferase 1 / 0.753
4u9y COAAlpha-tubulin N-acetyltransferase 1 / 0.743
1i12 ACOGlucosamine 6-phosphate N-acetyltransferase / 0.742
2fxf ACODiamine acetyltransferase 1 / 0.742
5kf2 ACOPredicted acetyltransferase / 0.741
4if5 ACOAlpha-tubulin N-acetyltransferase 1 / 0.739
1tiq COASpermidine/spermine N(1)-acetyltransferase / 0.738
5kgj ACOPredicted acetyltransferase / 0.738
1z4r ACOHistone acetyltransferase KAT2A 2.3.1.48 0.735
2b3v ACODiamine acetyltransferase 1 / 0.734
4b5o ACOAlpha-tubulin N-acetyltransferase 1 / 0.734
4gs4 ACOAlpha-tubulin N-acetyltransferase 1 / 0.730
1s3z COAAminoglycoside N(6')-acetyltransferase type 1 / 0.728
4zm6 ACON-acetyl-beta-D glucosaminidase / 0.728
2cy2 ACOProbable acetyltransferase / 0.726
1l0c COTSerotonin N-acetyltransferase / 0.723
5h86 BCOHistone acetyltransferase KAT2A 2.3.1.48 0.721
1cjw COTSerotonin N-acetyltransferase / 0.719
2zpa ACOtRNA(Met) cytidine acetyltransferase TmcA / 0.717
2x7b COAN-alpha-acetyltransferase 2.3.1 0.714
2vez ACOGlucosamine 6-phosphate acetyltransferase, putative / 0.713
3mgd ACOPredicted acetyltransferase / 0.712
3r95 ACOMccE protein / 0.712
2ob0 ACON-alpha-acetyltransferase 50 / 0.710
3s6f COAUncharacterized protein / 0.708
2q4v ACODiamine acetyltransferase 2 2.3.1.57 0.707
2vzz SCAPutative succinyl-CoA transferase Rv0802c 2.8.3 0.705
4ua3 COAN-alpha-acetyltransferase 40 2.3.1 0.704
3r96 ACOMccE protein / 0.701
4qvt ACOAcetyltransferase YpeA 2.3.1 0.699
4xnh ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.699
2ft0 ACOdTDP-fucosamine acetyltransferase / 0.698
3vwe COAAlpha-tubulin N-acetyltransferase 1 / 0.695
1s7n COAAcetyl transferase / 0.694
4jwp ACOGCN5-related N-acetyltransferase / 0.693
2c27 ACOMycothiol acetyltransferase 2.3.1.189 0.692
1pu9 COAHAT A1 / 0.690
3d2p COAAmino-acid acetyltransferase / 0.690
5h84 1VUHistone acetyltransferase KAT2A 2.3.1.48 0.686
1qsn COAHAT A1 / 0.684
4ri1 ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase 2.3.1.202 0.682
1p0h ACOMycothiol acetyltransferase 2.3.1.189 0.680
4kub COAUncharacterized protein / 0.680
3f0a ACOSpermidine N(1)-acetyltransferase / 0.679
2bei ACODiamine acetyltransferase 2 2.3.1.57 0.678
5kf8 COAPredicted acetyltransferase / 0.678
4crz ACOPanD regulatory factor / 0.676
3cz7 ACOHistone acetyltransferase RTT109 2.3.1.48 0.673
4u9v ACON-alpha-acetyltransferase 40 2.3.1 0.673
1j4j ACOAcetyltransferase 2.3.1 0.670
1kuv CA5Serotonin N-acetyltransferase / 0.668
1s5k COAAminoglycoside N(6')-acetyltransferase type 1 / 0.668
2a4n COAAac(6')-Ii protein / 0.668
5kf9 COAPredicted acetyltransferase / 0.666
2psw COAN-alpha-acetyltransferase 50 / 0.664
1ib1 COTSerotonin N-acetyltransferase / 0.662
2zfn ACOHistone acetyltransferase RTT109 2.3.1.48 0.661
3tfy COAN-alpha-acetyltransferase 50 2.3.1 0.661
1b87 ACOAac(6')-Ii protein / 0.659
1xvt COAL-carnitine CoA-transferase / 0.659
1ghe ACOAcetyltransferase 2.3.1 0.655
3zj0 ACOPutative acetyltransferase OgpAT / 0.655
2vxk COAGlucosamine 6-phosphate acetyltransferase, putative / 0.654
4xpd ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.651