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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3oa2 NAD UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 1.206
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.912
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.894
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.857
3q2k NAIProbable oxidoreductase / 0.828
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 0.796
3ec7 NADInositol 2-dehydrogenase / 0.783
1ofg NDPGlucose--fructose oxidoreductase 1.1.99.28 0.782
1zh8 NAPUncharacterized protein / 0.778
2glx NDP1,5-anhydro-D-fructose reductase / 0.770
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 0.765
5a02 NAPGlucose-fructose oxidoreductase / 0.751
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.749
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.745
3aw9 NADNAD-dependent epimerase/dehydratase / 0.745
3m2t NADProbable dehydrogenase / 0.744
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.741
5a03 NDPGlucose-fructose oxidoreductase / 0.736
5a04 NDPGlucose-fructose oxidoreductase / 0.734
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.732
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 0.730
5a06 NDPGlucose-fructose oxidoreductase / 0.730
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.728
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.726
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.722
3sx2 NADUncharacterized protein / 0.721
1h6b NDPGlucose--fructose oxidoreductase 1.1.99.28 0.717
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.717
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.714
3adp NAILambda-crystallin 1.1.1.45 0.712
5a05 NDPGlucose-fructose oxidoreductase / 0.712
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.708
5bsg NAPPyrroline-5-carboxylate reductase / 0.707
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.702
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.702
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.701
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.698
1eq2 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.697
4twr NADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase / 0.696
2wsb NADGalactitol dehydrogenase / 0.694
1nai NADUDP-glucose 4-epimerase 5.1.3.2 0.691
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.691
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.685
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.681
4plp NADHomospermidine synthase 2.5.1.44 0.681
2p5y NADUDP-glucose 4-epimerase / 0.679
3x2f NAIAdenosylhomocysteinase / 0.679
1lc3 NADBiliverdin reductase A 1.3.1.24 0.678
3dbv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.678
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.678
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.676
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.674
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.674
3ggp NADPrephenate dehydrogenase / 0.674
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.674
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.674
3nt2 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.673
3hwr NDP2-dehydropantoate 2-reductase / 0.670
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.670
4cr8 NADN-acylmannosamine 1-dehydrogenase 1.1.1.233 0.670
2g82 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.669
4lk3 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.669
4l8v NAPInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.668
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.667
3ikt NADRedox-sensing transcriptional repressor Rex / 0.667
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.665
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.663
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.663
3dmt NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.661
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.661
4xqc NADHomospermidine synthase 2.5.1.44 0.661
3tri NAPPyrroline-5-carboxylate reductase / 0.660
4tvb NADHomospermidine synthase 2.5.1.44 0.660
1xcb NADRedox-sensing transcriptional repressor Rex / 0.659
2qg4 UGAUDP-glucose 6-dehydrogenase 1.1.1.22 0.659
2vna NAPProstaglandin reductase 2 1.3.1.48 0.659
3bts NADGalactose/lactose metabolism regulatory protein GAL80 / 0.659
3i6q NDPPutative leucoanthocyanidin reductase 1 / 0.659
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.658
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.658
4xgi NADGlutamate dehydrogenase / 0.658
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.657
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.657
2pv7 NADT-protein 1.3.1.12 0.656
5bt9 NAP3-oxoacyl-(Acyl-carrier-protein) reductase / 0.656
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.655
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.655
3zl8 ADPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase / 0.654
4boy NADGlyceraldehyde-3-phosphate dehydrogenase / 0.654
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.653
3lvf NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.653
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.652
1n7h GDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.652
2f1k NAPPrephenate dehydrogenase / 0.652
2voj NADAlanine dehydrogenase 1.4.1.1 0.652
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.651
3d64 NADAdenosylhomocysteinase / 0.651
4b7x NAPProbable oxidoreductase / 0.650