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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3m6i NAD L-arabinitol 4-dehydrogenase 1.1.1.12

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 1.066
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.876
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.873
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.802
4cpd NADAlcohol dehydrogenase / 0.797
2d8a NADL-threonine 3-dehydrogenase / 0.796
2dfv NADL-threonine 3-dehydrogenase / 0.783
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.770
2dph NADFormaldehyde dismutase / 0.765
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.764
3jv7 NADSecondary alcohol dehydrogenase / 0.755
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.751
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.751
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.751
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.750
4jk3 NADUncharacterized protein / 0.750
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.747
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.747
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.746
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.746
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.743
4j43 NADUncharacterized protein / 0.743
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.740
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.739
4j49 NADUncharacterized protein / 0.738
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.737
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.731
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.731
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.731
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.730
4rqu NADAlcohol dehydrogenase class-P / 0.730
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.729
4oaq NDPR-specific carbonyl reductase / 0.727
2vhx NADAlanine dehydrogenase 1.4.1.1 0.726
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.724
1u7h NADPutative ornithine cyclodeaminase / 0.724
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.724
1x7d NADPutative ornithine cyclodeaminase / 0.722
3wle NAD(R)-specific carbonyl reductase / 0.722
2cdc NAPGlucose 1-dehydrogenase / 0.721
2xaa NADSecondary alcohol dehydrogenase / 0.720
1uxj NADMalate dehydrogenase / 0.715
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.714
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.714
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.713
4c4o NADSADH / 0.712
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.711
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.708
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.704
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.702
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.702
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.701
4l0q NADAlcohol dehydrogenase class-3 / 0.701
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.701
4i1i NADMalate dehydrogenase / 0.700
4j49 NAIUncharacterized protein / 0.699
2cda NAPGlucose 1-dehydrogenase / 0.696
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.695
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.695
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.693
4jji NADAlcohol dehydrogenase class-3 / 0.692
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.691
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.690
1uxk NADMalate dehydrogenase / 0.690
1b8v NADMalate dehydrogenase / 0.688
3two NDPMannitol dehydrogenase / 0.688
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.687
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.686
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.686
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.686
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.686
4ejm NAPPutative zinc-binding dehydrogenase / 0.686
1bdm NAXMalate dehydrogenase / 0.685
1sow NADL-lactate dehydrogenase 1.1.1.27 0.685
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.682
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.682
2voj NADAlanine dehydrogenase 1.4.1.1 0.682
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.681
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.681
1ie3 NADMalate dehydrogenase / 0.680
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.680
3uko NADAlcohol dehydrogenase class-3 / 0.680
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.677
1gv0 NADMalate dehydrogenase / 0.677
1b8u NADMalate dehydrogenase / 0.673
3wsw NADL-lactate dehydrogenase / 0.673
2ejv NADL-threonine 3-dehydrogenase / 0.672
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.672
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.671
2nad NADFormate dehydrogenase / 0.670
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.669
1pzh NADLactate dehydrogenase / 0.669
2x0r NADMalate dehydrogenase / 0.669
1yqd NAPSinapyl alcohol dehydrogenase / 0.667
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.667
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.666
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.662
1ib6 NADMalate dehydrogenase / 0.662
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.662
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.660
2ome NADC-terminal-binding protein 2 / 0.660
1wze NADMalate dehydrogenase / 0.659
2gsd NADFormate dehydrogenase / 0.659
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.659
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.656
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.656
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.656
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.655
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.655
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.654
1pjc NADAlanine dehydrogenase / 0.654
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.653
4z0p NDPNAD-dependent dehydrogenase / 0.653
5a1t NAIL-lactate dehydrogenase / 0.653
1bmd NADMalate dehydrogenase / 0.652
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.651
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.651
1llu NADAlcohol dehydrogenase / 0.650