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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hvi 619 Catechol O-methyltransferase 2.1.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3hvi 619Catechol O-methyltransferase 2.1.1.6 1.276
3hvk 719Catechol O-methyltransferase 2.1.1.6 1.198
3nwb 659Catechol O-methyltransferase 2.1.1.6 1.165
3nwe 662Catechol O-methyltransferase 2.1.1.6 1.082
3r6t LU1Catechol O-methyltransferase 2.1.1.6 1.054
3nw9 637Catechol O-methyltransferase 2.1.1.6 1.020
3oe4 610Catechol O-methyltransferase 2.1.1.6 0.975
1jr4 CL4Catechol O-methyltransferase 2.1.1.6 0.912
3ozt OZZCatechol O-methyltransferase 2.1.1.6 0.903
3oe5 611Catechol O-methyltransferase 2.1.1.6 0.901
3a7d FBNCatechol O-methyltransferase 2.1.1.6 0.836
3ozr OZRCatechol O-methyltransferase 2.1.1.6 0.825
3ozs OZSCatechol O-methyltransferase 2.1.1.6 0.796
2zvj KOMCatechol O-methyltransferase 2.1.1.6 0.720
5fhq DNCCatechol O-methyltransferase 2.1.1.6 0.714
3c3y SAHO-methyltransferase / 0.704
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.704
5fa5 MTAProtein arginine N-methyltransferase 5 / 0.704
4m37 SAHProtein arginine N-methyltransferase 7 2.1.1 0.693
4tm3 FADKtzI / 0.691
1b8s FADCholesterol oxidase 1.1.3.6 0.690
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.689
4gqb 0XUProtein arginine N-methyltransferase 5 / 0.688
1wy7 SAHUncharacterized protein / 0.687
4kwc SAHMethyltransferase domain family / 0.686
1d2h SAHGlycine N-methyltransferase 2.1.1.20 0.684
1sqf SAMRibosomal RNA small subunit methyltransferase B 2.1.1.176 0.684
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.682
2cl5 BIECatechol O-methyltransferase 2.1.1.6 0.677
1cbo FADCholesterol oxidase 1.1.3.6 0.676
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.676
2gew FADCholesterol oxidase 1.1.3.6 0.676
3cbg SAHO-methyltransferase / 0.675
4xvy SAHMycinamicin III 3''-O-methyltransferase 2.1.1.237 0.674
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.671
2pwy SAHtRNA (adenine(58)-N(1))-methyltransferase TrmI 2.1.1.220 0.671
3v8v SAMRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.669
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.664
4yuz S4MSpermidine synthase, putative / 0.663
1l3i SAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) / 0.661
5f8f SFGPossible transcriptional regulatory protein / 0.661
3ict FADCoenzyme A disulfide reductase / 0.659
2hv9 SFGmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.658
3geg NADShort-chain dehydrogenase/reductase SDR / 0.658
1v59 NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.656
2jib ADPOxalyl-CoA decarboxylase 4.1.1.8 0.653
2y1x SAHHistone-arginine methyltransferase CARM1 / 0.653
3g8a SAHRibosomal RNA small subunit methyltransferase G / 0.653
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
4b65 FADL-ornithine N(5)-monooxygenase / 0.653
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.652
4xcx SAHSmall RNA 2'-O-methyltransferase / 0.652
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.651
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.651
1f8w FADNADH peroxidase 1.11.1.1 0.650