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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hrf ATP 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.890
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.819
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.812
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.797
4rqv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.754
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.740
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.739
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.738
3hrc ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.733
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.730
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.728
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.727
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.724
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.722
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.720
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
2biy ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.707
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
4ct1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.705
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.704
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.703
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.703
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.700
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.699
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.697
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.695
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
4ysj ADPCalmodulin-like domain protein kinase / 0.692
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.691
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.689
1h1w ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.688
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.688
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.687
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.687
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.687
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.684
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.683
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.679
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.678
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.676
3ork AGSSerine/threonine protein kinase / 0.674
5ack ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.674
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.672
4fg9 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.672
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.669
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.668
5ckw ANPUncharacterized protein / 0.666
3gu8 3GUDeath-associated protein kinase 1 2.7.11.1 0.665
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.664
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.662
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.662
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.658
3orp AGSSerine/threonine protein kinase / 0.656
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.656
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.655
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.653
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.653
4j95 ACPFibroblast growth factor receptor 2 / 0.651
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.650
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.650