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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ehj ACP Sensor histidine kinase DesK 2.7.13.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ehj ACPSensor histidine kinase DesK 2.7.13.3 0.961
1i58 ACPChemotaxis protein CheA 2.7.13.3 0.758
4gt8 ADPSensor protein VraS 2.7.13.3 0.757
4gqt ADPHeat shock protein 90 / 0.716
1th8 ADPAnti-sigma F factor / 0.715
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.711
1i59 ANPChemotaxis protein CheA 2.7.13.3 0.702
1yt0 ADPEndoplasmin / 0.701
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.689
1z59 ADPType 2 DNA topoisomerase 6 subunit B / 0.685
4wuc ANPDNA gyrase subunit B / 0.685
1y4s ADPChaperone protein HtpG / 0.684
1byq ADPHeat shock protein HSP 90-alpha / 0.683
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.679
4xcj ADPHeat shock cognate 90 kDa protein / 0.677
4xcl AGSHeat shock cognate 90 kDa protein / 0.676
4xeo A5AAlanine--tRNA ligase, cytoplasmic / 0.676
3t2s AGSHeat shock protein HSP 90-alpha / 0.675
4prv ADPDNA gyrase subunit B / 0.674
1i59 ADPChemotaxis protein CheA 2.7.13.3 0.673
1i5c ADPChemotaxis protein CheA 2.7.13.3 0.672
4bix ADPSensor histidine kinase CpxA / 0.669
2ior ADPChaperone protein HtpG / 0.668
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.664
4prx ADPDNA gyrase subunit B / 0.663
3pzc GAPAmino acid--[acyl-carrier-protein] ligase 1 6.2.1.n2 0.662
1i5a ACPChemotaxis protein CheA 2.7.13.3 0.660
2xcm ADPCytosolic heat shock protein 90 / 0.659
1i5b ANPChemotaxis protein CheA 2.7.13.3 0.658
4r1f ADPDNA topoisomerase 2-alpha 5.99.1.3 0.656
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.655
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.655
1i58 ADPChemotaxis protein CheA 2.7.13.3 0.654
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.654
4dt8 ADNAPH(2'')-Id / 0.654
3b2t M33Fibroblast growth factor receptor 2 / 0.653
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.652
3e9h KAALysine--tRNA ligase 6.1.1.6 0.652
1amw ADPATP-dependent molecular chaperone HSP82 / 0.651
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.651
4xc0 ACPHeat shock cognate 90 kDa protein / 0.651
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.650