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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cot STR 3-oxo-5-beta-steroid 4-dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 1.089
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4e5l DBHPolymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.738
4nky 3QZSteroid 17-alpha-hydroxylase/17,20 lyase / 0.726
1kdm DHTSex hormone-binding globulin / 0.725
3eqm ASDAromatase 1.14.14.14 0.704
3s79 ASDAromatase 1.14.14.14 0.698
1d2s DHTSex hormone-binding globulin / 0.697
1kdk DHTSex hormone-binding globulin / 0.697
1ya3 STRMineralocorticoid receptor / 0.697
2b01 TUDPhospholipase A2, major isoenzyme 3.1.1.4 0.697
3w5p 4OAVitamin D3 receptor / 0.696
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.695
2jn3 JN3Fatty acid-binding protein, liver / 0.694
5dxg ESTEstrogen receptor / 0.690
4pxm ESTEstrogen receptor / 0.689
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.688
2qgt EEDEstrogen receptor / 0.683
4ofu DHTAndrogen receptor / 0.680
2q7i TESAndrogen receptor / 0.678
4ofr DHTAndrogen receptor / 0.678
1t7f DHTAndrogen receptor / 0.677
3zqt TESAndrogen receptor / 0.677
2ft9 CHDFatty acid-binding protein 2, liver / 0.675
2lba CHOFatty acid binding protein 6 / 0.673
3uud ESTEstrogen receptor / 0.673
1f5f DHTSex hormone-binding globulin / 0.672
4r21 STRCytochrome P450 family 17 polypeptide 2 / 0.672
1lhn AONSex hormone-binding globulin / 0.671
2ab2 SNLMineralocorticoid receptor / 0.671
3vhu SNLMineralocorticoid receptor / 0.671
3q95 ESLEstrogen receptor / 0.670
3w5q 3KLVitamin D3 receptor / 0.669
1y5r C0RCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.668
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.666
1t79 DHTAndrogen receptor / 0.666
3w5r LOAVitamin D3 receptor / 0.666
4oez DHTAndrogen receptor / 0.665
1gwr ESTEstrogen receptor / 0.664
1lhw ESMSex hormone-binding globulin / 0.664
4j6d TESCytochrome P450 monooxygenase / 0.664
5hyr ESTEstrogen receptor / 0.664
2ama DHTAndrogen receptor / 0.663
3cav CI23-oxo-5-beta-steroid 4-dehydrogenase / 0.663
2yja ESTEstrogen receptor / 0.662
4q0a 4OAVitamin D3 receptor A / 0.662
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.661
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3d90 NOGProgesterone receptor / 0.659
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.659
1lke DOGBilin-binding protein / 0.657
2oax SNLMineralocorticoid receptor / 0.656
2ocf ESTEstrogen receptor / 0.656
3bej MUFBile acid receptor / 0.656
3l03 4OHEstrogen receptor / 0.656
4hlw TESAndrogen receptor / 0.655
2aa7 1CAMineralocorticoid receptor / 0.654
2aax PDNMineralocorticoid receptor / 0.654
2abi 1CAMineralocorticoid receptor / 0.651
2pnu ENMAndrogen receptor / 0.650
2qo5 CHDFatty acid-binding protein 10-A, liver basic / 0.650